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https://www.sciencedirect.com/science/article/pii/S0169409X03002394
2. Transdermal drug delivery using microneedles. The overarching motivation for microneedles is that they can provide a minimally invasive means to transport molecules into the skin. Guided by this goal, a number of specific strategies have been employed to use microneedles for transdermal delivery.Author: Mark R Prausnitz
https://www.sciencedirect.com/science/article/pii/S0142961207010605
Dissolving microneedles for transdermal drug delivery. (a) Microneedle master-structure (600 μm in height and 300 μm wide at base) used to mold dissolving microneedles made of (b) CMC, (c) amylopectin and (d) BSA. The master-structure was imaged by scanning electron microscopy and the molded microneedles were imaged by brightfield microscopy.Author: Jeong Woo Lee, Jung-Hwan Park, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum.Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered …Author: Kevin B. Ita
https://www.dermarollershop.com/blog/microneedles-transdermal-drug-delivery-dynamic-duo/
One of the major uses of microneedles is transdermal drug delivery. But the success of this route has severely limited by the inability of some medications to enter the skin at a therapeutically useful rate. Just recently, there is an increasing use of micron-scale needles in increasing the skin permeability. It has been shown that […]
https://www.ondrugdelivery.com/wp-content/uploads/2017/05/1060_GF_ONdrgDelivery_Issue-56_-transdermal_MR.pdf
Drug Delivery Systems. Reproduced with kind permission. ONdrugDelivery Issue No 56, March 31st, 2015 Transdermal Delivery & Microneedles This edition is one in the ONdrugDelivery series of publications from Frederick Furness Publishing. Each issue focuses on a specific topic within the field of drug delivery, and is supported by industry leaders
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Expert opinion: In past years, there has been a crescent of advances in the development of microneedles as a drug delivery system by researchers and pharmaceutical companies. The authors observed patents related to manufacture of dissolving, hydrogel-forming, solid, hollow and coated microneedles for ocular and transdermal drug delivery.
https://archives.drugabuse.gov/news-events/nida-notes/2014/03/microneedle-milestone-one-week-transdermal-drug-delivery
Mar 13, 2014 · Figure. Microneedles Enable Continuous Transdermal Drug Delivery for 7 Days With diclofenac to keep micropores patent, a single microneedles application sustained therapeutic concentrations of naltrexone for 1 week. The graph shows levels of naltrexol, the active metabolite of naltrexone, in blood plasma.
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