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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137519/
Apr 06, 2016 · Coated microneedles. Advancement on solid MNs was the development of coated devices. Solid MNs are pre-coated with a vaccine in a formulation suitable for coating and dissolution, 1 thus resulting in a one-step delivery process. The vaccine coated MNs are inserted into the skin, where dissolution of the vaccine occurs.Author: Sarah Marshall, Laura J. Sahm, Anne C. Moore
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794664/
Oct 14, 2019 · Microneedle Delivery of Vaccine. Traditionally, most vaccines are administered intramuscularly or subcutaneously, and the route of administration is relatively painful. Today, MNs array system has been widely studied for delivery of vaccine and is …
https://www.researchgate.net/publication/259743922_Microneedle_Patches_for_Vaccine_Delivery
But the successful utilization of this system for vaccine drug delivery mainly depends on design of device to facilitate microneedle infusion, vaccine stability and storage in system, recovery of ...
https://www.ondrugdelivery.com/simplified-drug-vaccine-delivery-using-microns-microneedle-patch/
SIMPLIFIED DRUG AND VACCINE DELIVERY USING MICRON’S MICRONEEDLE PATCH . EARLY INSIGHT Citation: McAllister DV, Henry S, Prausnitz M, “Simplified Drug and Vaccine Delivery Using Micron’s Microneedle Patch”. ONdrugDelivery Magazine, Issue 84 (Mar 2018), pp 20-23.
https://www.sciencedirect.com/science/article/pii/S0169409X12001251
Microneedles for drug and vaccine delivery ... Delivery with a microneedle patch is envisioned as an alternative to hypodermic injection that is less painful, safer and simpler for patients to self administer. Because the doses of biotherapeutics are often low (i.e., microgram doses), many biotherapeutics can be administered either coated onto ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12001251
Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells.Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.cdc.gov/globalhealth/immunization/stories/microneedle-patch.htm
Apr 01, 2015 · He believes that, “A major advantage of the microneedle patch would be the ease of delivery.” Rather than the vaccine coming in a vial that must be drawn up by needle-and-syringe for injection, the microneedle patches come with the vaccine encapsulated within the dissolvable microneedles and are simply placed on the skin.
https://www.dovepress.com/technology-update-dissolvable-microneedle-patches-for-vaccine-delivery-peer-reviewed-fulltext-article-MDER
Considering the above-mentioned challenges with parenteral, oral and traditional ID delivery routes, recent research efforts have focused on addressing the urgent and unmet requirement for simplified, alternative methods for vaccine delivery. Microneedle (MN) patches have been proposed as an innovative vaccine delivery platforms and a viable ...Author: Aoife M Rodgers, Ana Sara Cordeiro, Ryan F Donnelly
https://www.medscape.com/viewarticle/766506_2
Oct 21, 2019 · Influenza vaccine-coated solid microneedle delivery to the skin of mice could induce virus neutralizing antibody and hemagglutination inhibition responses at comparable (or higher) levels to the ...
https://www.hindawi.com/journals/jir/2019/8303648/
Intradermal immunization for vaccine delivery is an upcoming strategy showing significant advantages over conventional vaccination routes. In particular, in the last few years, intradermal vaccination has gained momentum as an alternative and more effective vaccine delivery route, both from a scientific and a commercial point of view (Table 3).Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
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