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https://www.sciencedirect.com/science/article/pii/S0169409X00001125
The eye is a unique organ system comprised of a number of important sites amenable to examination with microdialysis. In a simplistic sense, the eye can be viewed as a two compartment system (): the anterior segment (containing the cornea/conjunctiva/sclera externally and the anterior chamber, iris/pupil, posterior chamber and ciliary body internally) and the posterior segment (containing the ...Author: Kay D Rittenhouse, Gary M Pollack
https://www.researchgate.net/publication/12219101_Microdialysis_and_drug_delivery_to_the_eye
The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for treatment of ocular diseases.
https://www.ncbi.nlm.nih.gov/pubmed/11108976
Dec 15, 2000 · 1. Adv Drug Deliv Rev. 2000 Dec 15;45(2-3):229-41. Microdialysis and drug delivery to the eye. Rittenhouse KD(1), Pollack GM. Author information: (1)Preclinical Sciences, Bausch and Lomb Pharmaceuticals, Tampa, FL 33637, USA. The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for ...Author: Kay D Rittenhouse, Gary M Pollack
https://www.deepdyve.com/lp/elsevier/microdialysis-and-drug-delivery-to-the-eye-D0urCMDxd8
Dec 15, 2000 · Microdialysis and drug delivery to the eye Microdialysis and drug delivery to the eye Rittenhouse, Kay D; Pollack, Gary M 2000-12-15 00:00:00 The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for treatment of ocular diseases. In this paper, we present a discussion of the anatomical and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/45/issue/2
Read the latest articles of Advanced Drug Delivery Reviews at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
https://www.researchgate.net/publication/7495944_Microdialysis_assessment_of_drug_delivery_systems_for_vitreoretinal_targets
Microdialysis assessment of drug delivery systems for vitreoretinal targets Article · Literature Review in Advanced Drug Delivery Reviews 57(14):2080-91 · January 2006 with 12 Reads
https://www.liebertpub.com/doi/abs/10.1089%2F108076801753266866
Drug Delivery to the Eye Validation of an ocular microdialysis technique in rabbits with permanently implanted vitreous probes: systemic and intravitreal pharmacokinetics of fluorescein International Journal of Pharmaceutics, Vol. 281, No. 1-2Author: Sreeraj MacHa, Ashim K. Mitra
http://ijpsr.com/bft-article/a-novel-ophthalmic-drug-delivery-system-in-situ-gel/?view=fulltext
ABSTRACT. The ophthalmic in-situ gels now days proved an palpable sustained drug delivery in various eye diseases.The formulation of in-situ gels for eye which carries the advantages like easy for administration, reduces frequency of dose and improves patient compliance.The formation of in-situ gels depends on phase transition system or sol-gel transition system.
https://www.future-science.com/doi/full/10.4155/bio.10.2
The unique anatomy and physiology of the eye present many challenges to the successful development and delivery of ophthalmic drugs. Any therapeutic strategy developed to control the progression of anterior and posterior segment diseases requires continuous monitoring of effective drug concentrations in the relevant ocular tissues and fluids.Author: Sai Hs Boddu, Sriram Gunda, Ravinder Earla, Ashim K Mitra
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