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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials.Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://pubs.acs.org/doi/10.1021/la503929c
Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a minimally invasive and highly targeted therapy. While lipid MBs have been approved for use as contrast agents in diagnostic ultrasound, the attachment ...Author: Conor McEwan, Colin Fowley, Nikolitsa Nomikou, Bridgeen McCaughan, Anthony P. McHale, John F. Callan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889676/
The key to success for microbubbles as drug delivery vehicles is their extreme activity when exposed to ultrasonic waves. The gas core expands during the rarefaction phase of the pressure wave and contracts during the compression phase.Author: Shashank Sirsi, Mark Borden
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers.Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
https://www.sciencedirect.com/science/article/pii/S0168365917307605
Magnetically responsive microbubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose Bengal (RB) and/or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreatic cancer using combined antimetabolite and …Author: Yingjie Sheng, Estelle Beguin, Heather Nesbitt, Sukanta Kamila, Joshua Owen, Lester C. Barnsley, Bri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662343/
Apr 23, 2007 · The well was filled with approximately 1 mL of Dulbecco’s phosphate buffered saline with Ca 2+ and Mg 2+ (DPBS, Invitrogen) solution containing approximately 10 7 delivery vehicles (either liposome-bearing microbubbles or microbubbles only). In order to compare the delivery efficiency of liposome-bearing microbubbles with liposomes using ultrasound, liposomes with a similar formulation to those carried by microbubbles …Author: Azadeh Kheirolomoom, Paul A. Dayton, Aaron F.H. Lum, Erika Little, Eric E. Paoli, Hairong Zheng, Kat...
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