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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials.Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
An ideal drug delivery system would deliver a sufficient dose of drug in the entire target volume. The drug delivery profile of ultrasound mediated drug delivery in the tissues, however, is …Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
http://ijpsr.com/bft-article/the-concept-of-microbubble-as-a-drug-delivery-system-an-overview/?view=fulltext
Microbubbles in general have a wide variety of applications. They are used as a contrast agent in diagnosis. They are widely applicable in gene delivery due to its very important silent feature. Majorly main huge research is going on drug delivery by microbubble with ultra sound.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/microbubble
16.3.1.3 Microbubble drug delivery Microbubbles can provide deep penetration into the body tissues; however, their cargo space is generally small and is usually confined to the nonfluorous shell. The drug-loading capacity can be increased by increasing the size of the shell but only at the expense of image sensitivity, as larger shells are more rigid and less compressible.
https://radiologykey.com/microbubble-assisted-ultrasound-for-drug-delivery-in-the-brain-and-central-nervous-system/
Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System Fig. 16.1 The Blood-Brain Barrier (BBB) is composed of endothelial cells that are connected to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720159/
Jun 30, 2008 · 3. Ligand-mediated targeting of microbubbles and potential use for drug delivery. The development of targeted contrast agents extended ultrasound-based imaging to the depiction of molecular and cellular processes. The principle relies on the accumulation of the contrast agent at the specific molecular sites in the body.Author: Sophie Hernot, Sophie Hernot, Alexander L. Klibanov
https://www.researchgate.net/publication/235005004_THE_CONCEPT_OF_MICROBUBBLE_AS_A_DRUG_DELIVERY_SYSTEM_AN_OVERVIEW
THE CONCEPT OF MICROBUBBLE AS A DRUG DELIVERY SYSTEM: AN OVERVIEW. Micro bubbles are small spherical type of bubble which consists of a gas, they are separated from each other, so they cannot agglomerates. Actually, they have size range in micrometers usually 1-100 micrometer.Author: Hitesh Katariya
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