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https://www.sciencedirect.com/science/article/pii/S092809870200221X
These include prodrugs and synthetic or natural polymer-based delivery systems. This article aims at reviewing the various microbially activated drug delivery systems for colon-specific drug delivery with specific reference to the microflora of the various segments of the gastrointestinal tract and their role in targeting drug delivery to the ...Author: V.R Sinha, Rachna Kumria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · a. pH Sensitive Polymer Coated Drug Delivery to the Colon . In the stomach, pH ranges between 1 and 2 during fasting but increases after eating.18 The pH is about 6.5 in the proximal small intestine, and about 7.5 in the distal small intestine.19 From the ileum to the colon, pH declines significantly. It is about 6.4 in the cecum.Author: Anil K. Philip, Betty Philip
https://www.researchgate.net/publication/10929258_Microbial_triggered_drug_delivery_to_colon
Microbial triggered drug delivery to colon. ... This article aims at reviewing the various microbially activated drug delivery systems for colon-specific drug delivery with specific reference to ...
https://www.ncbi.nlm.nih.gov/pubmed/12554067
Colon, the distal part of the intestine is inhabited by a large variety of gram negative microflora. This flora produces a vast number of enzymes which are being exploited for formulation of colon-specific drug delivery systems. A number of microbially activated systems for …Author: V.R Sinha, Rachna Kumria
https://www.sciencedirect.com/science/article/abs/pii/S092809870200221X
A number of microbially activated systems for colon-specific drug delivery are being evaluated. These include prodrugs and synthetic or natural polymer-based delivery systems. This article aims at reviewing the various microbially activated drug delivery systems for colon-specific drug delivery with specific reference to the microflora of the ...Author: V.R Sinha, Rachna Kumria
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · Colon targeted drug delivery systems 1. ONTARGET Targeted Drug Delivery Systems Dr. Gajanan S. Sanap M.Pharm.,Ph.D Department of Pharmaceutics Ideal College of Pharmacy and Research Kalyan 421- 306 COLON TARGETED DRUG DELIVERY 2.
http://ijpsr.com/bft-article/a-review-on-colon-targeted-drug-delivery-system/?view=fulltext
Microbially Triggered Drug Delivery to Colon: Principle: Drug release in colon via degradation of biodegradable polymers coated on the dosage forms by microflora present in colon, because colon is rich in microorganisms. These dosage form protected from upper GIT, due to very little microbial degradable activity in upper GIT is present which is ...
https://www.japsonline.com/admin/php/uploads/363_pdf.pdf
colon through pH sensitive system, microbially triggered system i.e., prodrugs and polysaccharide release system. Keywords: Colon specific drug delivery, pH sensitive, time controlled dependent, microbially d and osmotically controlled system. INTRODUCTION Drug delivery to the colon should be capable of protecting the drug en route to the colon
https://www.researchgate.net/publication/265251646_STUDIES_ON_MICROBIALLY_TRIGGERED_ENTERIC_COATED_TABLETS_FOR_COLON_TARGETED_DELIVERY_OF_MESALAMINE
The results also demonstrated that a Eudragit® S100 can be successfully used for aqueous & organic system to coat tablets for colon targeted delivery of drug. For colon targeted delivery of drugs ...
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.511.1963
The proportion of guar gum exhibited predominant action as compared to coat weight. The guar gum–HPMC coating was found to be a promising drug delivery system for colon targeting. Key words- colon targeting, compression coating, microbially triggered system, guar gum, HPMC K4M,site specific drug delivery, enzyme activated.
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