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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/protein-drug-delivery
One strategy to improve peptide and protein drug delivery to the CNS consists of combining systemic administration of the drug with transient osmotic opening of the BBB. Osmotic opening of the BBB was one of the earliest techniques to circumvent it for therapeutic purposes [41].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
The PLGA microspheres for protein delivery can be prepared by several methods with the most widely used techniques for proteins conjugation being: (i) spray drying, (ii) double emulsion, and (iii) phase separation-coacervation. 92Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Application of an electric current disrupts the structure of these lipids, allowing molecules to penetrate the skin. In addition, delivery of drug can be increased using this method by increasing the voltage, number of pulses and duration of pulses to levels still viewed as safe for the patient . Due to the high complexity of these systems, no peptides have been FDA approved for delivery by electroporation.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/pii/S1773224715300058
Drug and protein delivery by polymer conjugation has open new pathway of research. It is important to remember that the development of complex coupling strategies such as glycoPEGylation, a double-step enzymatic approach which generates conjugates, was considered impossible only a few decades ago.Author: Antonella Grigoletto, Katia Maso, Anna Mero, Antonio Rosato, Oddone Schiavon, Gianfranco Pasut
https://www.nature.com/articles/nchem.2629
Oct 21, 2016 · Biological drugs generated via recombinant techniques are uniquely positioned due to their high potency and high selectivity of action. The major drawback of this class of therapeutics, however, is their poor stability upon oral administration and during subsequent circulation.Author: Alexander N. Zelikin, Carsten Ehrhardt, Anne Marie Healy
https://www.researchgate.net/publication/304814091_Synthesis_of_protein_nanoparticles_for_drug_delivery
Among them, drug delivery system based on protein nanoparticles has been widely studied aiming to overcome deficiency of drug-loaded materials, such as low biocompatibility, inefficient ...
https://www.slideshare.net/BrajeshKumar67/protein-and-peptide-drug
May 24, 2015 · Number of approaches are available for effective protein and peptide drug delivery. They are IONTOPHORESIS PHONOPHORESIS PENETRATION ENHANCERS PRODRUG Iontophoresis: Used for local and systemic delivery of proteins and peptides.
https://www.researchgate.net/publication/328265448_PROTEIN_AND_PEPTIDE_DRUG_DELIVERY_SYSTEM
PROTEIN AND PEPTIDE DRUG DELIVERY SYSTEM. Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, …
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in …
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