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https://www.jpsmjournal.com/article/S0885-3924(15)00164-5/fulltext
Injectable methadone may be unavailable or not desired, and the rectal, transmucosal, or transdermal routes are acceptable alternatives. The choice of alternative route depends on patient-specific factors, and it is important to have a number of options to be able to meet the needs of all patients.Author: Philippa Hawley, Petrina Wing, Shalini Nayar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884589/
Oct 01, 2003 · Rectal administration of methadone may be an alternative to intravenous and oral dosing in cancer pain, but the bioavailability of the rectal route is not known. The aim of this study was to compare the absolute rectal bioavailability of methadone with ...Author: Ola Dale, Ola Dale, Pamela Sheffels, Evan D. Kharasch
https://www.drugs.com/dosage/methadone.html
Oct 14, 2019 · -Patients receiving methadone maintenance for opioid dependence cannot be expected to derive analgesia from their methadone; if acute pain occurs and requires treatment, these patients may require higher and/or more frequent doses than non-tolerant patients due to the opioid tolerance induced by methadone.8.7/10
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2125.2004.02116.x
Rectal methadone was shown to be an acceptable alternative to oral hydromorphone or morphine in patients requiring high dose opioids [3, 4, 25, 26]. Relatively little is known about the pharmacokinetics of rectal methadone, and its absolute rectal bioavailibility has not been determined.Author: Ola Dale, Ola Dale, Pamela Sheffels, Evan D. Kharasch
http://med-fom-fpit.sites.olt.ubc.ca/files/2015/10/Non-Oral-Methadone-Article.pdf
methadone when the oral route is no longer available. Injectable methadone may be unavailable or not desired, and the rectal, transmucosal, or transdermal routes are acceptable alternatives. The choice of alter-native route depends on patient-specific factors, and it is important to have a number of options to be able to meet the needs of all patients.
https://www.macycatheter.com/
The Macy Catheter is the best alternative for rapid administration of medication and fluids. Patented and FDA cleared, the Macy Catheter provides access to the clinically proven rectal route of delivery. Faster. Safer. More Cost Effective.
https://www.webmd.com/mental-health/addiction/what-is-methadone
Methadone is a powerful drug used for pain relief and treatment of drug addiction. Learn more about what methadone is, why it’s used, side effects, risks, and how to store and dispose of it.
https://academic.oup.com/painmedicine/article/15/7/1129/1877709
Jul 24, 2014 · Rectal Methadone Rectal administration in this patient was effective, well tolerated, and cost efficient. Maloney, 1989 Retrospective review 39 patients with terminal illness Rectal MS Contin ® Twenty-seven of the patients experienced equivalent analgesia with no change in side effects when the route was changed from oral to rectal.Author: Matthew G. Kestenbaum, Agustin O. Vilches, Stephanie Messersmith, Stephen R. Connor, Perry G. Fine, ...
https://en.wikipedia.org/wiki/Methadone
Methadone acts by binding to the µ-opioid receptor, but also has some affinity for the NMDA receptor, an ionotropic glutamate receptor. Methadone is metabolized by CYP3A4, CYP2B6, CYP2D6 and is a substrate for the P-glycoprotein efflux protein in the intestines and brain.Formula: C₂₁H₂₇NO
http://www.calhospice.org/included/docs/education/2014/conference/Pre-ConA-Brad_Macy.pdf
AtlernateRoutes of Medication Administration for End of Life Symptom Management LIFE -COMPARING EFFECTIVENESS, VERSATILITY, COST, AND EASE OF USE IN THE ... Alternate Routes of Medication Delivery Rectal (Suppositories) ... Opiates-(Morphine, fentanyl, Hydromorphone,methadone, more) X X X X Fentanyl Fentanyl NSAIDS-(Ibuprofen, Indomethacin, ASA ...File Size: 1MB
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