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https://www.pharmamanufacturing.com/articles/2015/efficient-development-of-generic-metered-dose-inhalers/
Jun 03, 2015 · Like many drug delivery technologies, development of Metered Dose Inhalers (MDIs) is a technical challenge. Formulators must ensure that the finished product is safe, efficacious for the duration of the product shelf life, and that it complies with the requirements of the current regulatory landscape.
https://www.nicklauschildrens.org/care-guides/drug-delivery-devices-metered-dose-inhalers-and-s
Drug delivery devices: Metered dose inhalers and spacers The metered dose inhaler (MDI) is the most common device people use to take asthma medication. An MDI allows you to inhale a specific amount of medicine (a "metered dose").
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969484/
Jan 23, 2014 · Pressurized metered dose inhalers (MDIs) are a long-standing method to treat diseases of the lung, such as asthma and chronic obstructive pulmonary disease. MDIs rely on the driving force of the propellant, which comprises the bulk of the MDI formulation, to atomize droplets containing drug and excipients, which ideally should deposit in the lungs.Author: Paul B. Myrdal, Poonam Sheth, Stephen W. Stein
http://www.rcjournal.com/contents/09.05/09.05.1177.pdf
Metered-Dose Inhaler In the first half of the 20th century, inhaled drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) were mostly delivered via hand-held, squeeze-bulb nebulizers. These devices were fragile, and since the dose varied with hand pressure, they did not provide consistent drug delivery.
https://www.ondrugdelivery.com/dry-powder-inhalers-towards-effective-affordable-sustainable-respiratory-healthcare/
Delivery efficiency. To deliver the drug as efficiently as possible to where it needs to go in the airways remains the number one goal. Developers will continue their drive to improve drug delivery efficiency to the lung through reduction of losses in the device and the …
https://drug-dev.com/a-next-generation-inhaled-dry-powder-delivery-platform/
Traditional inhaled drug delivery has used a number of technologies, including pressurized metered dose inhalers (pMDIs), nebulizers, and dry powder inhalers (DPIs). While delivery of drugs via these first-generation inhaled drug systems provides great advantages over oral or intravenous delivery, these systems also have inherent limitations.
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
completion of the dose delivery blow, the nasal/oral connection returns to its normal open state (see figure 1). This delivery method holds the potential to become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug ...
https://www.sciencedirect.com/science/article/pii/S0091674995702075
Drug delivery from an MDI results from a complex interaction between the formulation, valve, and actuator. Several factors contribute to the dose reproducibility of MDIs. Although these factors may be transient and not representative of the average behavior of MDI performance during routine use, such differences may still be of clinical importance.Author: Robert K. Schultz
https://www.sciencedirect.com/science/article/pii/S0954611117300136
Optimizing drug delivery in COPD: The role of inhaler devices ... (VHCs), breath-actuated metered-dose inhalers (BA-MDIs), dry powder inhalers (DPIs), soft mist inhalers (SMI), and nebulizers , . The characteristics, advantages and disadvantages of the currently available inhaler devices are reported in …Author: Paola Rogliani, Luigino Calzetta, Angelo Coppola, Francesco Cavalli, Josuel Ora, Ermanno Puxeddu, Ma...
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