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http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1568-0266&volume=12&issue=2&spage=89
Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.Author: B. Naeye, K. Raemdonck, K. Remaut, J. Demeester, S. C. De Smedt
https://www.researchgate.net/publication/51922122_Matrix_Systems_for_siRNA_Delivery
Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of...
https://biblio.ugent.be/publication/5735671
Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623593/
Therefore, a delivery strategy that stabilizes siRNA, provides intracellular (cytoplasmic) delivery, and produces temporally sustained activity is needed. The novel approach described combines pH-responsive, siRNA-loaded nanoparticles into a biodegradable polyurethane (PUR) scaffold and presents a promising platform for effective, local silencing of deleterious genes in nonhealing skin wounds.Author: Christopher E. Nelson, Mukesh Kumar Gupta, Elizabeth J. Adolph, Scott A. Guelcher, Craig L. Duvall
https://www.nature.com/articles/s41427-018-0027-4
Apr 12, 2018 · Ideal siRNA delivery vehicles should be engineered from biocompatible materials and should be able to effectively entrap siRNA, facilitate its cellular uptake and improve its pharmacological properties by protecting it from serum nucleases, renal filtration, and uptake by the mononuclear phagocyte system 10,11.Author: Xin Li, A-ning Sun, Yu-jie Liu, Wen-jie Zhang, Ning Pang, Shi-xuan Cheng, Xian-rong Qi
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
One example of a polymeric siRNA delivery system in clinical trials is the Dynamic PolyConjugates system, which enabled >60% silencing of apoB in hepatocytes in vivo at a dose of about 2.5 mg/kg (50 μg siRNA and 800 μg polymer per mouse) .Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues.Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Directly conjugation of delivery materials to siRNA has been shown to be a promising system for siRNA delivery. The most common conjugate materials are small drug molecules, aptamers, lipids, peptides, proteins and polymers [84]. This system has a quite obvious …Author: Cong-fei Xu, Jun Wang
https://www.researchgate.net/publication/51243923_SiRNA_Delivery_challenges_and_role_of_carrier_systems
Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provide options for desirable engineering of carrier particles. In this review, there is a detailed discussion of RNAi delivery systems and recent advances in the field.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
Polymers for Drug Delivery Systems. ... (or dispersed if the concentration exceeds the polymer's solubility limit) in a nonswellable or fully swollen matrix that does not degrade during its therapeutic life. ... Ongoing work aims to optimize these systems for intracellular small interfering RNA (siRNA) delivery.Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
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