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https://link.springer.com/chapter/10.1007/978-1-4613-2745-5_16
In general, the term matrix device implies a drug delivery system in which the drug is dispersed, either molecularly or as solid drug particles, within a polymer network. Within this context at least four different types of devices can be envisioned.Author: John R. Cardinal
https://promedmolding.com/implantable-drug-delivery-devices-overview/
Dec 18, 2017 · Implantable drug delivery devices offer several advantages over conventional oral or parenteral dosage forms. First, implantable devices allow site specific drug administration where the drug is most needed. Examples include implants used in the treatment of brain tumors (Gliadel® wafer) or prostate cancer (Lupron® depot).
https://www.mddionline.com/polymers-controlled-drug-delivery
Drug delivery from a typical matrix drug delivery system. For the reservoir systems shown in Figures 3a and 3b, the drug delivery rate can remain fairly constant. In this design, a reservoir whether solid drug, dilute solution, or highly concentrated drug solution within a polymer matrix is surrounded by a film or membrane of a rate-controlling ...
https://en.wikipedia.org/wiki/Modified-release_dosage
Diffusion systems can be broken into two subcategories, reservoir devices and matrix devices. Reservoir devices coat the drug with polymers and in order for the reservoir devices to have sustained release effects, the polymer must not dissolve and let the drug be released through diffusion.
https://ocw.mit.edu/courses/materials-science-and-engineering/3-051j-materials-for-biomedical-applications-spring-2006/lecture-notes/lecture19.pdf
Lecture 19 Drug Delivery: Controlled Release What do we mean by “controlled” release? Control of: 1. delivery rate ... (drug concentration above solubility limit in matrix) ⇒ Drug dissolution in polymer matrix limits release rate ... Membrane Controlled Devices Drug release is controlled by a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430809/
This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria.Author: Cynthia L. Stevenson, John T. Santini, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977044/
Except for the formulation A, which is a matrix tablet and the simplest controlled release drug delivery system composed of the drug and the carrier/retarding polymeric material, all the other devices (based on A) had the two surfaces of the core (top and bottom) covered with Carbopol barriers, thus the formulation consisted of a three-layer ...Author: M. Efentakis, C. Peponaki
https://www.tepha.com/platforms/drug-delivery/
Processed at lower temperatures for improved drug stability DESCRIPTION: Tepha is developing and formulating TephaFLEX® and TephELAST® materials into a number of treatment-specific constructs for local delivery as well as systemic release of small molecule drugs and biological therapeutics.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-release
Zoraida P. Aguilar, in Nanomaterials for Medical Applications, 2013. 5.7 Drug Release and Biodegradation. Drug release refers to the process by which the drug loaded in or on the NMs is released in the body through diffusion or dissolution of the NMs matrix releasing the drug in solution. Biodegradation refers to the process by which the drug delivery system is broken down inside the body.
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