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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518665/
Jan 10, 2013 · This review aims to highlight mechanistic, mathematical models that address the role of autocatalysis in the mass transport and chemical reaction phenomena of drug delivery from PLGA microspheres. The place of these types of models in the broader context of mathematical models for polymeric drug delivery systems is illustrated in Fig. 3.Author: Ashlee N. Ford Versypt, Ashlee N. Ford Versypt, Daniel W. Pack, Daniel W. Pack, Richard D. Braatz, R...
https://www.sciencedirect.com/science/article/pii/S0168365912007353
Several mathematical models have been developed for the in vitro drug release kinetics from polymeric drug delivery devices (see Table 1, Table 2).This review aims to highlight mathematical models that mechanistically address the role of autocatalysis in the mass transport and chemical reaction phenomena of drug delivery from PLGA microspheres.Author: Ashlee N. Ford Versypt, Ashlee N. Ford Versypt, Daniel W. Pack, Daniel W. Pack, Richard D. Braatz, R...
https://www.sciencedirect.com/science/article/abs/pii/S0168365912007353
Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review ☆ Author links open overlay panel Ashlee N. Ford Versypt a …Author: Ashlee N. Ford Versypt, Ashlee N. Ford Versypt, Daniel W. Pack, Daniel W. Pack, Richard D. Braatz, R...
https://dspace.mit.edu/openaccess-disseminate/1721.1/101153
Ford Versypt, Ashlee N., Daniel W. Pack, and Richard D. Braatz. “Mathematical Modeling of Drug Delivery from Autocatalytically Degradable PLGA Microspheres — A Review.” Journal of Controlled Release 165, no. 1 (January 2013): 29–37.Author: Ashlee N. Ford Versypt, Daniel W. Pack, Richard D. Braatz
http://web.mit.edu/braatzgroup/mathematical_modeling_of_drug_delivery_from_autocatalytically_degradable_plga_microspheres_a_review.pdf
Review Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review☆ Ashlee N. Ford Versypt a,b, Daniel W. Pack a,c, Richard D. Braatz a,b,⁎ a Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA b Department of Chemical Engineering, Massachusetts Institute of Technology…
https://www.researchgate.net/publication/232719960_Mathematical_Modeling_of_Drug_Delivery_from_Autocatalytically_Degradable_PLGA_Microspheres-A_Review
Mathematical Modeling of Drug Delivery from Autocatalytically Degradable PLGA Microspheres—A Review. PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer.
https://www.aiche.org/conferences/aiche-annual-meeting/2013/proceeding/paper/666a-mechanistic-modeling-plga-microsphere-drug-delivery-analytical-autocatalytic-degradation-1
Biodegradable PLGA microspheres have been extensively studied as drug delivery devices [1-4]. Modeling of the drug release from the devices must consider the interdependent phenomena that contribute to drug release [1,5]; the most significant of the phenomena are autocatalytic polymer degradation and drug diffusion.
http://onlinelibrary.wiley.com/doi/10.1002/jps.10463/abstract
7 Ashlee N. Ford Versypt, Daniel W. Pack, Richard D. Braatz, Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review, Journal of Controlled Release, 2013, 165, 1, 29CrossRef
https://www.researchgate.net/publication/251468380_Multi-Scale_Modeling_of_PLGA_Microparticle_Drug_Delivery_Systems
A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release.
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