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https://www.tandfonline.com/doi/abs/10.1517/17425247.5.6.693
Oct 08, 2008 · Background: M (microfold or membranous) cells are specialised epithelial cells responsible for antigen sampling at the interface of mucosal surfaces and the environment. Their high transcytotic ability make M cells an attractive target for mucosally delivered vaccines and therapeutics.Author: Rhonda KuoLee, Wangxue Chen
https://www.researchgate.net/publication/5324603_M_cell-targeted_delivery_of_vaccines_and_therapeutics
This brief review discusses the current state of M cell-targeted mucosal delivery systems and the potential of such delivery systems for the development of new vaccines and therapeutics against...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509160/
In particular, M cells are responsible for antigen uptake into MALT, and the rapid and effective transcytotic activity of M cells makes them an attractive target for mucosal vaccine delivery, although simple transport of the antigen into M cells does not guarantee the induction of …Author: Sae-Hae Kim, Kyung-Yeol Lee, Yong-Suk Jang
https://www.sciencedirect.com/science/article/pii/B9780128119242000286
Taken together with the results obtained by UEA-1 and NKM16-2-4 above, unique glycosylated molecule(s) produced by M cells could be considered as the M cell-specific …Author: Shintaro Sato, David W. Pascual
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514083/
Nov 01, 2014 · M-cell-targeting ligands can enhance the uptake of oral vaccines by M cells and improve antigen-specific immune responses in both mucosal and systemic immunity. It seems that targeting ligand to antigen is a very promising approach in the development of efficient mucosal vaccine.Author: Miao Wang, Zeqian Gao, Zhongwang Zhang, Li Pan, Yongguang Zhang
https://www.sbir.gov/sbirsearch/detail/1308811
Jul 18, 2017 · RNA-based vaccines and therapeutics have emerged as great promise for HIV prevention and treatment, respectively. However, many obstacles still need to be overcome, in particular RNA instability, manufacturing problems, and clinically relevant delivery …
https://www.nature.com/articles/emm2013165
Mar 14, 2014 · The origin and development of M cells. The origin of M cells in FAE of PP was unclear until recently. 43 It was identified by ‘lineage tracing’ that Lgr5 (leucine-rich repeat-containing G protein-coupled receptor 5)-expressing stem cells in crypt are the origin of all intestinal epithelial cells …Author: Sae-Hae Kim, Yong-Suk Jang
https://www.sciencedirect.com/science/article/pii/S0734975011001285
As commercial approval of the first, purified, plant-based biopharmaceuticals for parenteral delivery to humans approaches, improved strategies for delivery of plant-made vaccines and therapeutics are required to ensure their further development and to fulfil the prospect of supplying a global solution for affordable medicines.Author: Assunta Pelosi, Robert Shepherd, Amanda Maree Walmsley
https://www.frontiersin.org/journals/all/sections/vaccines-and-molecular-therapeutics
Vaccines and Molecular Therapeutics welcomes submissions of the following article types: Case Report, Classification, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Systematic Review and Technology and Code.
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