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https://www.sciencedirect.com/science/article/pii/S0169409X09002828
In particular, these engineering approaches can be used in the context of localized drug delivery to selectively capture a therapeutic payload and control its release in local proximity to its target. Recently, environmental stimulation has become an intense area of research for the development of unique materials that can (1) form safely ...Author: Narayan Bhattarai, Jonathan Gunn, Miqin Zhang
https://www.drugdiscoverytrends.com/localized-drug-delivery-promises-to-improve-outcomes-and-reduce-side-effects/
Jun 26, 2018 · Localized drug delivery refers to technology used to limit the presentation of a drug to a desired body site for its release and absorption, or the subsequent transport of the active ingredients across the biological membranes to the site of action. The aim of such approaches is to improve the bioavailability of the drug at the site of disease ...
https://www.bme.ufl.edu/labs/stabler/research/localized-drug-delivery/
Localized Drug Delivery; Localized Drug Delivery. An additional aspect of functionalization of our macroporous scaffold platform is in the incorporation of anti-inflammatory or immunomodulatory agents for the purpose of long-term, localized release.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073348/
Localized cell and drug delivery to the cochlea and central auditory pathway can improve the safety and performance of implanted auditory prostheses (APs). While generally successful, these devices have a number of limitations and adverse effects including ...Author: Jeffrey L. Hendricks, Jennifer A. Chikar, Mark A. Crumling, Yehoash Raphael, David C. Martin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201908/
Nov 30, 2014 · Improving pharmacokinetic and pharmacodynamic profiles, overcoming short-half life issues, and using localized delivery whenever possible could lower bacterial resistance incidence . Local, controlled antibiotic release leads to lower dosing, decreased toxicity, extended release, and avoidance of systemic exposure [9, 10].Author: Nicholas D. Stebbins, Michelle A. Ouimet, Kathryn E. Uhrich
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
A topical (used on the skin) antibacterial ointment for a localized infection or a cortisone injection of a painful joint can avoid some of the systemic side effects of these medications. There are other ways to achieve targeted drug delivery, but some medications can only be given systemically.
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