Local And Systemic Delivery Of Sirnas For Oligonucleotide Therapy

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Local and systemic delivery of siRNAs for oligonucleotide ...

    https://www.ncbi.nlm.nih.gov/pubmed/19301643
    Local and systemic delivery of siRNAs for oligonucleotide therapy. Takeshita F(1), Hokaiwado N, Honma K, Banas A, Ochiya T. Author information: (1)Section for Studies on Metastasis, National Cancer Center Research Institute, Tokyo, Japan.Author: Fumitaka Takeshita, Naomi Hokaiwado, Kimi Honma, Agnieszka Banas, Takahiro Ochiya

Local and Systemic Delivery of siRNAs for Oligonucleotides ...

    https://www.researchgate.net/publication/24215342_Local_and_Systemic_Delivery_of_siRNAs_for_Oligonucleotides_Therapy
    Local and Systemic Delivery of siRNAs for Oligonucleotides Therapy Article in Methods in Molecular Biology 487:83-92 · February 2009 with 10 Reads How we measure 'reads'

Local and Systemic Delivery of siRNAs for Oligonucleotides ...

    https://link.springer.com/protocol/10.1007%2F978-1-60327-547-7_4
    Oct 13, 2008 · Takeshita F., Hokaiwado N., Honma K., Banas A., Ochiya T. (2009) Local and Systemic Delivery of siRNAs for Oligonucleotides Therapy. In: Sioud M. (eds) siRNA and miRNA Gene Silencing. Methods in Molecular Biology (Methods and Protocols), vol 487.Author: Fumitaka Takeshita, Naomi Hokaiwado, Kimi Honma, Agnieszka Banas, Takahiro Ochiya

Oligonucleotide Therapies: The Past and the Present

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554547/
    Aug 01, 2015 · Beside this, the most common target organs are the liver and the eye. Martinez et al. recently wrote a very nice overview of different diseases that are targeted by, for example, siRNAs. 64. Treating diseases through targeting of a specific gene expressed in the liver is appealing because of the easy access of this organ by systemic delivery.Author: E LundinKarin, GissbergOlof, SmithC.I. Edvard

Challenges and Opportunities for Local and Systemic ...

    https://www.researchgate.net/publication/23266141_Challenges_and_Opportunities_for_Local_and_Systemic_Delivery_of_siRNA_and_Antisense_Oligonucleotides
    Challenges and Opportunities for Local and Systemic Delivery of siRNA and Antisense Oligonucleotides Article in Clinical Pharmacology & Therapeutics 84(5):628-32 · October 2008 with 83 Reads

Delivery systems for siRNA drug development in cancer therapy

    https://www.sciencedirect.com/science/article/pii/S1818087614000646
    However, the excellent therapeutic potential of siRNA for cancer therapy remains uncovered. It is necessary to introduce systemic routes of siRNA delivery to treat most cancers. As mentioned above, the design criteria of an in vivo, systemic siRNA delivery system should include biocompatibility, biodegradability, and non-immunogenicity ...Author: Cong-fei Xu, Jun Wang

Oligonucleotide therapy: An emerging focus area for drug ...

    https://www.sciencedirect.com/science/article/pii/S0009279719305757
    Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases ... as they act only on one mRNA target. siRNAs are responsible for gene silencing at the post transcriptional level by causing RNA interference (RNAi). ... McCaskill and co-workers studied the systemic delivery of cationic liposomes ...Author: Meenu Mehta, Deeksha, Devesh Tewari, Gaurav Gupta, Rajendra Awasthi, Harjeet Singh, Parijat Pandey, ...

Gene therapy progress and prospects: non-viral gene ...

    https://www.nature.com/articles/3302838
    Sep 05, 2006 · Hydrodynamic gene delivery, the first systemic delivery method for naked DNA, is a rapid injection of a large volume of naked DNA solution (e.g. 5 μg plasmid DNA injected in 5–8 s in 1.6 ml ...Author: Li Sd, Huang L

Oligonucleotide Discovery and Delivery - OPT Congres

    https://www.optcongress.com/oligonucleotide
    CHI’s Oligonucleotide Discovery and Delivery conference reveals the latest strategies at the forefront of discovery, chemistry and delivery with in-depth sessions on new chemistries, novel delivery mechanisms and the most important preclinical and clinical advances.

Systemic delivery of siRNA specific to tumor mediated by ...

    https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.24382
    Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl‐xL and cisplatin against prostate cancer ... enabling systemic delivery of siRNAs. 23 Takeshita et al. 23 previously showed the evidence of tumor targeted delivery of systemically ... Local or systemic administration of Bcl‐xL ...Author: Ping Mu, Shunji Nagahara, Naoki Makita, Yuzo Tarumi, Kenji Kadomatsu, Yoshifumi Takei

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