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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.Author: Daniel A. Balazs, Wt. Godbey
https://www.hindawi.com/journals/jdd/2011/326497/
Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.Author: Daniel A. Balazs, Wt. Godbey
https://www.sciencedirect.com/topics/neuroscience/liposomal-gene-delivery-system
This leaves “naked DNA” administration, liposomal gene delivery, and virally mediated gene transfer as the methods of choice for in vivo gene therapy application. Injection of “naked DNA” plasmids has been shown to result in intracranial gene expression. 2 However, with current technology, expression efficiency is very low and the practical value of this technique for brain tumor gene therapy remains …
https://www.crcpress.com/Liposomes-in-Gene-Delivery/Lasic/p/book/9780849331091
Liposomes in Gene Delivery covers both-molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
In gene delivery, various factors like liposomal preparation, size, and various types of liposomes such as cationic and anionic are responsible for the efficiency of transfection of the gene. First-generation liposomes in gene delivery suffered from several limitations such as poor encapsulation efficiency, poor release, and lower in vivo targetibility.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200004
One important goal for gene therapy is to develop a delivery system that can be injected into the bloodstream and deliver the DNA sequence to the appropriate tissue. The use of conventional liposomes for gene therapy implies a preferential localization in the liver, spleen and lung.
https://www.slideshare.net/DurgaBhavani60/liposomal-gene-delivery-system
Jul 14, 2019 · CONCLUSION: The shape of liposomes that are formed are determined by the types of lipids used, which, in turn, provides various options regarding delivery. The cationic head group appears to be better suited for DNA delivery while anionic head groups are perhaps better suited for drug delivery. One must keep in mind all of the variables that come into play when using different gene delivery …
https://www.researchgate.net/publication/12950633_Liposomes_as_a_gene_delivery_system
Since liposomes can easily bind to the cell surface, they have been used as nonviral vectors for gene delivery (Ropert, 1999). Unlike nonviral vectors, viral gene delivery systems have improved ...
https://pubs.rsc.org/en/content/articlelanding/2020/bm/d0bm00331j
Development of new self-assembled cationic amino liposomes for efficient gene delivery - Biomaterials Science (RSC Publishing) A library of 83 structurally diverse cationic amino liposomes are rationally designed and parallelly synthesized for transfection of of plasmid DNA and siRNA.
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