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https://www.sciencedirect.com/science/article/pii/S0922338X97873321
From the results of preliminary animal test, the liposomal delivery system for taxol showed promising aspects of diminished side effects and higher therapeutic effects, as compared to the ethanol/Cremophor EL formulation. The survival results of mice treated with or without taxol in using various taxol …Author: Meng-Feng Shieh, I-Ming Chu, Chau-Jen Lee, Pei Kan, Dou-Mong Hau, Jiunn-Jay Shieh
https://www.sciencedirect.com/science/article/abs/pii/S0922338X97873321
Encapsulation of taxol (paclitaxel) by liposomes provides an environment that enhances the solubility of taxol and avoids side effects caused by Cremophor EL, the emulsifier currently used. In this study, a suitable formula and production method for the liposomal delivery system were investigated.Author: Meng-Feng Shieh, I-Ming Chu, Chau-Jen Lee, Pei Kan, Dou-Mong Hau, Jiunn-Jay Shieh
https://www.cancernetwork.com/ovarian-cancer/liposomal-encapsulated-chemotherapy-preliminary-results-phase-i-study-novel-liposomal-paclitaxel
Sep 30, 2019 · The advancement of the liposomal drug-delivery system in the oncology field was predicated on preclinical and clinical data demonstrating the benefits of liposomal encapsulation of chemotherapeutic agents. Some of the liposomal preparations significantly increase the half-life of the incorporated agent vs that of the free drug.[10-13]Author: Joseph Treat, Nevena Damjanov, Cho Huang, Steven Zrada, Aquilar Rahman
https://www.hindawi.com/journals/jdd/2011/629234/
A liposome formulation for paclitaxel was developed in this study. The liposomes, composed of naturally unsaturated and hydrogenated phosphatidylcholines, with significant phase transition temperature difference, were prepared and characterized. The liposomes exhibited a high content of paclitaxel, which was incorporated within the segregated microdomains coexisting on phospholipid bilayer of ...Author: Pei Kan, Chih-Wan Tsao, Ae-June Wang, Wu-Chou Su, Hsiang-Fa Liang
https://www.uspharmacist.com/article/drug-delivery-systems-for-cancer-therapeutics
Sep 20, 2011 · Nanoparticle-based drug delivery systems include liposomes, micelles, and albumin microparticles. 6,7 TABLE 1 lists some drug delivery system technologies or platforms that have been approved for cancer therapy. 3-5 Of these systems, liposomal drug delivery is the most successful and is used to treat breast and ovarian cancers and Kaposi’s ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806207/
Feb 18, 2013 · Paclitaxel Nano-Delivery Systems: A Comprehensive Review. ... (50:50, v/v) a combination known as Taxol. However, Taxol has some severe side effects related to Cremophor EL and ethanol. Therefore, there is an urgent need for the development of alternative Taxol formulations. ... This dual-drug loaded nanocapsule delivery system was shown to be ...Author: Ping Ma, Russell J. Mumper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019274/
Sep 06, 2016 · Group of mice treated with Taxol underwent a temporary weight loss of ~11% during treatment while no significant weight loss was observed by liposomal PTX treatment (Figure 7B). It indicates that the toxicity of Taxol, which may be associated with the use of Cremophor, could be overcome when PTX was loaded in triglyceride-incorporated liposomes.Author: Soon-Seok Hong, Ju Yeon Choi, Jong Oh Kim, Mi-Kyung Lee, So Hee Kim, Soo-Jeong Lim
https://www.researchgate.net/publication/230878652_Liposomal_paclitaxel_formulations
Over the past three decades, taxanes represent one of the most important new classes of drugs approved in oncology. Paclitaxel (PTX), the prototype of this class, is an anti-cancer drug approved ...
https://en.wikipedia.org/wiki/Liposome
A liposome is a spherical vesicle having at least one lipid bilayer.The liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs. Liposomes can be prepared by disrupting biological membranes (such as by sonication).. Liposomes are most often composed of phospholipids, especially phosphatidylcholine, but may also include other lipids, such as egg ...
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · A magnetically driven paclitaxel delivery system has been designed by incorporating iron oxide and a drug in a palmitoyl chitosan matrix through a nanoprecipitation method for controlled drug ...Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
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