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https://www.precisionnanosystems.com/areas-of-interest/formulations/lipid-nanoparticles
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral gene delivery system. Lipid nanoparticles safely and effectively deliver nucleic acids, overcoming a major barrier preventing the development and use of genetic medicines. Genetic medicine has many different applications such as gene editing, rapid vaccine development, immuno-oncology and treatment of rare genetic and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
The LPD nanoparticle is stabilized by electrostatic interactions within the negatively charged nucleic acid–protamine complex core and positively charged lipid bilayer. This core-surface type of liposome was able to support the bilayer and tolerate a high level of PEG-DSPE (10 mol%) with a relatively dense PEG brush structure on the surface ...Author: Yi Zhao, Leaf Huang
https://www.nature.com/articles/am2017185
Oct 27, 2017 · Our work contributes to synthesize a vehicle based on lipid nanoparticles, which can effectively deliver Cas9/sgRNA-fused plasmid DNA in vitro and …Author: Lingmin Zhang, Lingmin Zhang, Peng Wang, Qiang Feng, Nuoxin Wang, Zitian Chen, Yanyi Huang, Wenfu Zh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885142/
Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies.Author: Anu Puri, Kristin Loomis, Brandon Smith, Jae-Ho Lee, Amichai Yavlovich, Eliahu Heldman, Robert Blume...
https://www.exeleadbiopharma.com/news/liposomes-and-lipid-nanoparticles-as-delivery-vehicles-for-personalized-medicine
Nov 16, 2018 · - Lipid nanoparticle delivery systems for siRNA-based therapeutics Wan C, Allen TM, Cullis PR 5 . Smaller batch sizes. Personalized drug product s are often manufactured in small batch sizes for single patients or small populations and can frequently result in less than one liter of product. In contrast, traditional manufacturing batches for ...
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