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https://www.precisionnanosystems.com/areas-of-interest/formulations/lipid-nanoparticles
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral gene delivery system. Lipid nanoparticles safely and effectively deliver nucleic acids, overcoming a major barrier preventing the development and use of genetic medicines. Genetic medicine has many different applications such as gene editing, rapid vaccine development, immuno-oncology and treatment of rare genetic and ...
https://acuitastx.com/technology/lipid-nanoparticles/
Acuitas specializes in the development of lipid nanoparticle delivery systems for molecular therapeutics. Our scientists have synthesized over 500 novel cationic lipids which have been evaluated in in vivo models. This evaluation characterizes the potency and safety of these LNP carriers for delivery of nucleic acids payloads including siRNA, mRNA, plasmid and antisense oligonucleotides.
https://www.biorxiv.org/content/10.1101/2020.01.16.907394v1
Jan 16, 2020 · Successfully employing therapeutic nucleic acids, such as small interfering RNA (siRNA), requires chemical modifications or the use of nanocarrier technology to prevent their degradation in the circulation and to facilitate intracellular delivery. Lipid nanoparticles (LNP) are among the most advanced nanocarriers culminating in the first siRNA therapeutic’s clinical translation and approval ...Author: Roy van der Meel, Roy van der Meel, Roy van der Meel, Sam Chen, Josh Zaifman, Jayesh A. Kulkarni, Xu...
https://pubs.acs.org/doi/10.1021/acs.accounts.9b00368
For efficient therapeutic siRNA delivery to hepatocytes, patisiran is critically dependent on lipid nanoparticle (LNP) technology.In this Account, we provide an overview of key advances that have been crucial for developing LNP delivery technology, and we explain how these developments have contributed to the clinical translation of siRNA ...Author: Jayesh A. Kulkarni, Dominik Witzigmann, Sam Chen, Pieter R. Cullis, Roy van der Meel, Roy van der Me...
https://www.precisionnanosystems.com/
Precision NanoSystems Announces Partnership with Fujifilm for the Development and GMP Manufacturing of Nanoparticle Based Therapeutics . ... NxGen technology is at the heart of the NanoAssemblr® family, ... Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo . N. Jyotsana, A. Sharma, A. Chaturvedi, et al. ...
https://genevant.com/platforms/
Our industry-leading lipid nanoparticle (LNP) platform has enabled clinical development of the most advanced RNA-based therapeutics. Our LNP platform is the only clinically-validated LNP delivery technology with safety and efficacy evaluated in over 400 patients across multiple clinical programs.
https://www.ncbi.nlm.nih.gov/pubmed/31397996
Sep 17, 2019 · Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics. ... Finally, we highlight patisiran's clinical translation and LNP delivery technology's potential to enable the development of genetic drugs beyond the current state-of-the-art, such as …Author: Jayesh A. Kulkarni, Dominik Witzigmann, Sam Chen, Pieter R. Cullis, Roy van der Meel, Roy van der Me...
https://drug-dev.com/nanoparticles-a-revolution-in-the-development-of-drug-delivery-vehicles/
The versatility of the NanoAssemblr technology means that it can also be applied to a variety of nanoparticle systems – liposomes, lipid nanoparticles, polymer particles, and micelles – offering research and development scientists the flexibility to explore a wide range of drug delivery mechanisms.
https://www.news-medical.net/whitepaper/20200130/Liposome-and-Lipid-Nanoparticle-for-Drug-Delivery-Applications.aspx
In liposome and lipid nanoparticle (LNP) drug-delivery applications, particle size is an important quality attribute (CQA) that can impact retention time, bioaccessibility and biodistribution.Author: Wyatt Technology
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