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https://www.sciencedirect.com/science/article/pii/S0928098711000984
In the following section, we will describe the use of lipid-mediated gene delivery in combination with delivery enhancing techniques for various cutaneous purposes. Due to the transient nature of gene expression inherent to this type of delivery, applications for DNA vaccination, wound healing, melanoma or other disorders that require temporary and reversible treatment are of most benefit.Author: Barbara Geusens, Tine Strobbe, Stefanie Bracke, Peter Dynoodt, Niek Sanders, Mireille Van Gele, Jo L...
https://www.semanticscholar.org/paper/Lipid-mediated-gene-delivery-to-the-skin.-Geusens-Strobbe/5f3a50914044cf68792ea66927bcb08957da0dcd
Clearly, lipid-based delivery vehicles demonstrate very promising results for DNA delivery into and through the skin, especially for cutaneous vaccination purposes. Apart from simple topical application onto the skin, liposomes have also been described in combination with delivery enhancing techniques.
https://www.researchgate.net/publication/51072402_Lipid-mediated_gene_delivery_to_the_skin
Lipid-mediated gene delivery to the skin. ... deoxycholate-mediated liposome (DOC-LS) endocytosis was employed to improve the antioxidation effects of OMC following topical administration, and the ...
https://biblio.ugent.be/publication/1956176
Lipid-mediated gene delivery to the skin Barbara Geusens ( UGent ) , TINE STROBBE ( UGent ) , STEFANIE BRACKE ( UGent ) , Peter Dynoodt ( UGent ) , Niek Sanders ( UGent ) , Mireille Van Gele ( UGent ) and Jo Lambert ( UGent )
https://www.frontiersin.org/articles/10.3389/fphar.2015.00219/full
Sep 30, 2015 · This article will summarize recent findings of lipid-based nano-delivery systems for skin delivery of drugs and bioactives agents. Skin barrier and permeabilityThe main barrier of the skin is located in the outermost layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by lipid regions.Author: Susan Hua
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588690/
Sep 30, 2015 · This article will summarize recent findings of lipid-based nano-delivery systems for skin delivery of drugs and bioactives agents. Skin barrier and permeability The main barrier of the skin is located in the outermost layer, the stratum corneum.Author: Susan Hua
https://www.sciencedirect.com/science/article/pii/S0076687903730286
To form lipid-DNA complexes suitable for gene delivery, a solution of plasmid or marker[14 C]-DNA is added to one of the liposome suspensions (I-XII) at various ratios (usually at DNA⧸liposome ratio 1:5, w⧸w). The mixture is shaken carefully and incubated for 30 min at room temperature.Author: Renat Zhdanov, Elena Bogdanenko, Alexey Moskovtsev, Olga Podobed, Nejat Düzgüneş
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1381-6128&volume=19&issue=41&spage=7301
Nanostructured vehicles (e.g. transfersomes, niosomes, nanoemulsions, gemini-lipid nanoparticles and biphasic vesicles) have the ability to partially disrupt and perturb lipids that are found in the skin layers and deliver their nucleic acid cargos to their targeted subcellular compartments.
http://www.eurekaselect.com/109082/article
Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies Author(s): Mahmoud Elsabahy , Marianna Foldvari . School of Pharmacy, University of …Author: Mahmoud Elsabahy, Marianna Foldvari
https://www.nature.com/articles/am2017185
Oct 27, 2017 · Among all the agents, Lipofectamine 3000 yielded the highest transfection efficiency (13.1%) ( Supplementary Table S1 ). Thus, the lipid systems may have great potential to carry large plasmids. Indeed, the lipid system is undoubtedly one of the most popular nonviral vehicles for gene delivery.Author: Lingmin Zhang, Lingmin Zhang, Peng Wang, Qiang Feng, Nuoxin Wang, Zitian Chen, Yanyi Huang, Wenfu Zh...
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