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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006685/
siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organelle membranes.Author: Shubiao Zhang, Shubiao Zhang, Defu Zhi, Leaf Huang
https://www.ncbi.nlm.nih.gov/pubmed/22994300
siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organelle membranes.Author: Shubiao Zhang, Shubiao Zhang, Defu Zhi, Leaf Huang
https://www.tandfonline.com/doi/abs/10.3109/1061186X.2012.719232
Nov 18, 2009 · siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organelle membranes.Author: Shubiao Zhang, Shubiao Zhang, Defu Zhi, Leaf Huang
https://www.researchgate.net/publication/230892888_Lipid-based_vectors_for_siRNA_delivery
The lipid-based vectors are the most commonly used vectors for RNAi delivery. They include cationic liposomes, solid lipid nanoparticles, solid nanostructured lipid carriers, lipidoids and pH-responsive lipids [74]. Many commercially available transfection agents (i.e., Lipofectamine, Oligofectamine,...
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2009.02189.x
Internalization of lipid‐based siRNA delivery systems into cells typically occurs through endocytosis; accordingly, delivery requires materials that can facilitate endosomal escape. The size of the carrier is important as carriers <100 nm in diameter have been reported to …Author: A. Schroeder, C. G. Levins, C. Cortez, R. Langer, D. G. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Lipid-based siRNA delivery systems include liposomes, micelles, microemulsions, and solid lipid nanoparticles . Liposomes are globular vesicles with an aqueous core and phospholipid bilayer, comprise natural body constituents (e.g., lipids, sterols…Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
SNALP technology from Tekmira Pharmaceuticals, Inc. is one of the most widely used lipid-based nucleic acid delivery approaches for systemic administration in clinical trials. Lipid vesicles encapsulating nucleic acids are formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution of nucleic acids in a controlled, stepwise manner.Author: Yi Zhao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Lipid-based vectors for anti-cancer siRNA delivery Lipofectamine 2000 is a kind of cationic lipid formulation that is widely used for in vitro plasmid DNA or siRNA transfection. Lipofectamine 2000 or the recently developed lipofectamine RNAimax are effective siRNA transfection agents in vitro which can improve the transfection efficacy by thousands of times [47] .Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Lipid- and polymer-based siRNA nanoparticles and conjugate systems enable successful delivery of chemically modified siRNAs in humans. Levels of …Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
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