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https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00013
Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little affinity for healthy cells but high affinity for pathologic cells.Author: Madduri Srinivasarao, Philip S. Low
https://www.sciencedirect.com/science/article/pii/B978012817909300008X
The ligand-targeted drug delivery system has a number of advantages over nontargeted systems. In case of a targeted drug delivery systems, the therapeutic warhead is targeted specifically to the diseased cell with the least exposure to normal healthy cells, …Author: Devesh Kapoor, Shailendra Bhatt, Manish Kumar, Rahul Maheshwari, Rakesh K. Tekade
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201904857
Mar 19, 2020 · Effective drug delivery systems that can systematically and selectively transport payloads to disease cells remain a challenge. Here, a targeting ligand‐modified DNA origami nanostructure (DON) as an antibody–drug conjugate (ADC)‐like carrier for targeted prostate cancer therapy is reported.Author: Zhilei Ge, Linjie Guo, Guangqi Wu, Jiang Li, Yunlong Sun, Yingqin Hou, Jiye Shi, Shiping Song, Lihua...
https://www.researchgate.net/publication/319658646_Ligand-Targeted_Drug_Delivery
Ligand-Targeted Drug Delivery. Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little …
https://www.researchgate.net/publication/12009053_Ligand-Receptor-Mediated_Drug_Delivery_An_Emerging_Paradigm_in_Cellular_Drug_Targeting
To date, several ligand-receptor systems have been studied for targeted drug delivery such as lectin receptors, Fc receptors, com- plement receptors, interleukin receptors, lipoprotein receptors ...
https://www.nature.com/articles/s41467-018-05384-1
Jul 30, 2018 · The stability of ligands is crucial to targeted drug delivery systems, thus d -peptide ligands are effective to preserve the bioactivity of ligands in blood circulation. However, preservation of IgM absorption leads to rapid clearance and enhanced immunogenicity.Author: Juan Guan, Qing Shen, Zui Zhang, Zhuxuan Jiang, Yang Yang, Meiqing Lou, Jun Qian, Weiyue Lu, Changyo...
https://www.nature.com/articles/nrd4519
Feb 20, 2015 · Typically, cytotoxic agents with nanomolar potencies are required in an effective ligand-targeted strategy, as receptor-mediated delivery may limit the maximum intracellular concentration of drug to 100 nM or less.Author: Madduri Srinivasarao, Chris V. Galliford, Philip S. Low
https://www.sciencedirect.com/science/article/pii/S1369702105710336
Targeted for drug delivery. ... This review focuses on targeted drug delivery using nanoparticles as a modality that couples a ligand to a nanosized, drug-loaded vehicle as a potential means to achieve increased efficacy of a drug at the site of interest.Author: Tarek M. Fahmy, Peter M. Fong, Amit Goyal, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · Targeted drug delivery refers to predominant drug accumulation within a target zone that is independent of the method and route of drug administration [ 9 ]. On the other hand, targeted therapy or targeted medicine means specific interaction between a drug and its receptor at the molecular level [ 10 – 12 ].Author: You Han Bae, Kinam Park
https://pubs.acs.org/doi/10.1021/mp500086e
Here we designed a retro-inverso isomer of LAngiopep, termed DAngiopep, to inspire brain-targeted drug delivery. Both DAngiopep and LAngiopep displayed high uptake capacity in LRP-1 overexpressed cells, including bEnd.3 and U87 cells.Author: Xiaoli Wei, Changyou Zhan, Xishan Chen, Jiapeng Hou, Cao Xie, Weiyue Lu
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