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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068128/
Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics Ryan G. Soderquist and Melissa J. Mahoney * Department of Chemical & Biological Engineering, University of Colorado at Boulder, 424 UCB, Boulder, CO 80309Author: Ryan G Soderquist, Melissa J Mahoney
https://qeprize.org/winners/q-a-controlled-release-large-molecule-drug-delivery
Dr Robert Langer was a founding figure in the field of large molecule controlled drug delivery. His training as a chemical engineer and fundamental understanding of the sciences enabled him to make advances at the intersection of new materials synthesis and applied engineering.
http://www.healthtech.com/datamonitor/largemoleculedrugs/toc/
Chapter 7 Conclusions 118 Summary 118 Introduction 119 Pharma vs biotech large molecule R&D investment 119 Leading technologies 121 Growth in particle engineering technologies 121 The impact of new routes of administration 122 Large molecule drug delivery market growth and …
https://www.drugdiscoverytrends.com/dermal-delivery-of-large-molecule-drugs/
Apr 11, 2013 · Scientists recently demonstrated that biphasic vesicles—a lipid-based, topical delivery system—can deliver large-molecule or macromolecule drugs into the skin. Success with biphasic vesicles offers the potential for needle-free administration of many pharmaceuticals that could previously only be administered by injection.
https://www.biopharma-reporter.com/Article/2018/09/14/The-third-generation-of-large-molecule-drugs-Controlled-release-biologics-says-DelSiTech
Sep 14, 2018 · “There are a large number of companies which have very promising compounds, but they can’t reach the target, which is the retina, because these compounds can’t be given orally. “We are focusing on intravitreal injections; this is a very hot topic in drug delivery in general,” he said.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/drug-delivery-of-small-molecule
Therefore, macromolecular drug carriers, such as dendrimers, are a great choice for pulmonary delivery of small-molecule drugs and peptides to prolong activity [137,138]. The multifunctional surface of dendrimers allows conjugation of drugs, targeting ligands and other groups to modify the physicochemical and pharmacokinetic properties of ...
https://www.enterabio.com/technology/oral-drug-delivery
Recently, drug development has shifted towards the use of peptides, proteins and other large molecules for the treatment of various diseases. By lowering the treatment burden on patients, oral drug delivery leads to higher patient and physician acceptance. In addition, oral drug delivery provides significantly more flexibility, both in size of dose and number of doses per day, than injectable drugs, which are …
http://blog.contractlaboratory.com/pharmaceutical-drug-development-small-molecules-large-molecules/
Mar 26, 2020 · Large molecules, or biologics, are classified as proteins having a therapeutic effect. In contrast to small molecule drugs, most large molecule drugs are complex and composed of more than 1,300 amino acids and are identical versions of human proteins.
http://www.drugdeliveryinstitute.com/events/advanced-drug-delivery-approaches/
Advanced Drug Delivery Approaches for Small & Large Molecules. THURSDAY, April 30, 2015 • 08:30 — 5:00. 3M Innovation Centre, Cain Road Bracknell RG12 8HT, United Kingdom.
https://www.westpharma.com/products/self-injection-platforms/smartdose?%20English
The SmartDose platform offers a wearable, subcutaneous injector with an integrated drug delivery system that incorporates human factors and usability testing to deliver a truly patient-centric approach to self-administration.
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