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https://www.researchgate.net/publication/12478694_Lamotrigine_in_Pregnancy_Pharmacokinetics_During_Delivery_in_the_Neonate_and_During_Lactation
To investigate the pharmacokinetics of lamotrigine (LTG) during delivery, during the neonatal period, and lactation. High-performance liquid chromatography was used to determine plasma and milk...
https://www.drugs.com/monograph/lamotrigine.html
Possible association between lamotrigine exposure during the first trimester of pregnancy and cleft lip or cleft palate in infants. 32 33 34. Physiologic changes during pregnancy may affect plasma lamotrigine concentrations and/or therapeutic effect. 1 43 (See Absorption: Special Populations
https://mothertobaby.org/fact-sheet-reference/lamotrigine-ref/
Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics; 122(1):e223-31. Nordmo E, et al. 2009. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother;43:1893-7. Ohman I, et al. 2000. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation.
https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2013.13010006
Lamotrigine Dosing for Pregnant Patients With Bipolar Disorder Crystal T. Clark, M.D., M.Sc. ... use of lamotrigine during pregnancy. Method: Lamotrigineserumsampleswere ... Postpartum Pharmacokinetics Lamotrigine serumlevelsreturn toprepregnancyvalues within 3 to 4 weeks after delivery (10, 12, 17). ...
https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.13010006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
The level-to-dose ratios were lower during pregnancy and at delivery than during the postpartum period . The changes in level-to-dose ratios varied between and within individuals across gestation. Ratios were lower during pregnancy than during the postpartum period for five patients (patients 1, …
http://journals.lww.com/drug-monitoring/Abstract/2008/08000/Changes_in_Lamotrigine_Pharmacokinetics_during.21.aspx
gnancies that could be assessed both during gestation and after delivery, plasma LTG concentrations increased on average by 164% (range +75 to +351%) between the last observation during pregnancy and the puerperium (P < 0.05). When all pregnancies monitored during pregnancy were considered, plasma LTG concentrations declined by an average of 20% (range -64% to +13%) between the first …
https://journals.lww.com/co-neurology/Fulltext/2009/04000/Managing_antiepileptic_drugs_during_pregnancy_and.8.aspx
Purpose of review This review discusses data on the pharmacokinetics of antiepileptic drugs (AEDs) in pregnancy and lactation, and the clinical consequences thereof, thus providing a basis for a rational management of AEDs during pregnancy and lactation.. Recent findings Studies have confirmed that the elimination of lamotrigine and the active metabolite of oxcarbazepine is enhanced during ...
http://www.uptodate.com/contents/management-of-epilepsy-and-pregnancy
This topic will discuss the management of epilepsy during pregnancy, delivery, and the postpartum period. The risks associated with epilepsy and the risks of antiepileptic drug (AED) treatment during pregnancy are discussed separately. ... Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate ...
https://link.springer.com/article/10.1007/s40262-019-00845-2
During pregnancy, the pharmacokinetics of an antiepileptic drug is altered because of changes in the clearance capacity and volume of distribution. These changes may have consequences for the frequency of seizures during pregnancy and fetal exposure to antiepileptic drugs. In 2009, a review was published providing guidance for the dosing and therapeutic drug monitoring of antiepileptic drugs ...
https://www.cfp.ca/content/56/11/1132
Lamotrigine (LTG) continues to increase in popularity1 for the treatment of epilepsy and bipolar disorder in the perinatal period. The safety data pertaining to fetal exposure to LTG during pregnancy are largely reassuring,2,3 but there are relatively few mother-infant pairs who have been studied systematically in the postpartum period. Concerns have been raised about the slow elimination half ...
https://www.sciencedirect.com/science/article/pii/S0920121117304485
Objective. To evaluate the impact of maternal UGT1A4 and UGT2B7 genetic polymorphisms and sex of foetus on gestation-induced changes in lamotrigine (LTG) clearance during pregnancy …
https://www.tandfonline.com/doi/pdf/10.1586/17512433.1.1.129
pharmacokinetics of these drugs are influenced in a simpler manner by physiological changes, such as pregnancy. However, within the last few years it has been established that the elimination of several newer AEDs is significantly accelerated during pregnancy. This is particularly the case for glucuronidated AEDs (i.e., lamotrigine) and the
https://www.medscape.org/viewarticle/764386
Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 48(6),6–1116 (2007). Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation.
https://link.springer.com/article/10.1007%2Fs00228-002-0544-4
Jan 30, 2003 · We studied transplacental passage of lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine; LTG) using an ex vivo human placental perfusion method and in in vivo samples. Term placentas from healthy mothers without medications were perfused in a recirculating dual perfusion system. LTG (2.5 μg/ml, n=4; 10 μg/ml, n=4) and reference compound antipyrine (100 μg/ml) were …
https://www.medscape.org/viewarticle/764386_2
Chen L, Liu F, Yoshida S, Kaneko S. Is breast-feeding of infants advisable for epileptic mothers taking antiepileptic drugs? Psychiatry Clin. Neurosci. 64(5), 5–468 (2010). Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 41(6), 6–713 (2000).
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