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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538444/
The development of the double-targeted drug carriers, which, in addition to prolonged circulation (via the attached PEG) and target recognition (via the attached antibody), carry the temporarily hidden function that can develop under the action of certain local stimuli (such as lowered pH), represent a significant step on the way towards “smart” multifunctional pharmaceutical nanocarriers capable of both target accumulation …Author: R.M. Sawant, J.P. Hurley, S. Salmaso, A. Kale, E. Tolcheva, T.S. Levchenko, V.P. Torchilin
https://pubs.acs.org/doi/10.1021/bc060080h
PH responsive polypeptide based polymeric micelles for anticancer drug delivery. Journal of Biomedical Materials Research Part A 2015 , 103 (9) , 3045-3053. DOI: 10.1002/jbm.a.35434.Author: R.M. Sawant, J.P. Hurley, S. Salmaso, A. Kale, E. Tolcheva, T.S. Levchenko, V.P. Torchilin
https://www.ncbi.nlm.nih.gov/pubmed/16848401
"SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Sawant RM(1), Hurley JP, Salmaso S, Kale A, Tolcheva E, Levchenko TS, Torchilin VP. Author information: (1)Department of Pharmaceutical Sciences, Northeastern …Author: R.M. Sawant, J.P. Hurley, S. Salmaso, A. Kale, E. Tolcheva, T.S. Levchenko, V.P. Torchilin
https://www.researchgate.net/publication/6938226_SMART_Drug_Delivery_Systems_Double-Targeted_pH-Responsive_Pharmaceutical_Nanocarriers
These environmentally-responsive NPs have therefore earned the epithet of 'smart' drug delivery systems, owing to their ability to modulate and control drug release inside the targeted cells [26 ...
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.691.2762
double-targeted ph-responsive pharmaceutical nanocarriers smart drug delivery system pnp-peg-pe moiety biotin-containing nanocarriers tatp-containing nanocarriers several function specific cell protective peg shell avidin column tatp-short peg-pe derivative u-87 cell certain local stimulus antibody substrate long-circulating pegylated liposome ph-degradable peg2000-pe acidic hydrolysis …
http://europepmc.org/abstract/MED/16848401
Jan 01, 2006 · To develop targeted pharmaceutical carriers additionally capable of responding to certain local stimuli, such as decreased pH values in tumors or infarcts, targeted long-circulating PEGylated liposomes and PEG-phosphatidylethanolamine (PEG-PE)-based micelles have been prepared with several functions.
https://www.sciencedirect.com/science/article/pii/S0165614718301007
MMP overexpression is remarkable and robust and can work as a tumor-specific stimulus, providing a ‘smart’ strategy for drug delivery and tumor targeting. The MMP-responsive systems may effectively deliver drugs, imaging agents, and other cargoes to the tumor and achieve tumor targeting at three levels: at the tissue, cellular, and ...Author: Qing Yao, Qing Yao, Longfa Kou, Ying Tu, Lin Zhu
http://www.idc-online.com/technical_references/pdfs/chemical_engineering/Introduction_to_smart_drug_delivery_system.pdf
2 Need for a ‘smart’ drug delivery system . An ideal drug delivery system needs to perform multiple functions, which requires the highest degree of smartness. Some of the major requisites of a drug delivery system are: • Improve solubility and stability of the drug/payload • Reduce the dosage as well as the frequency of dosage
http://www.thno.org/v06p1306.htm
Apart from the above-mentioned stimuli for smart DDSs, glucose [62-64] and electro-responsive systems [65-68] have also been employed to control the release of payloads within nanocarriers. Moreover, sensitivity to hybrid stimulus can further improve drug delivery accuracy.
https://www.sciencedirect.com/science/article/pii/S2211383514000252
Smart polymeric drug delivery systems have wide applications in the field of oral drug delivery of biological drugs which are sensitive to both gastric acid and enteric enzymes. Another application is in the field of smart diagnostics, since their use does not normally involve direct contact with the body.Author: Honey Priya James, Rijo John, Anju Alex, K.R. Anoop
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