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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852061/
Iontophoresis reduces intra and inter-subject variability in the delivery rate. This is an inherent disadvantage with the passive absorption technique. Experiments in vivo iontophoretic give support for clinical findings that there are small differences in the flux rate following transdermal iontophoresis between males and females, as well as between hairy and hairless skin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293348/
Dec 13, 2011 · Iontophoresis implies the use of a small amount of physiologically acceptable electric current (0.5 mA/cm 2 or less) to drive ionic (charged) drugs into the body by using an electrode of the same polarity as the charge on the drug. The drug is driven into the skin by electrostatic repulsion.
https://ijpsr.com/bft-article/iontophoresis-controlled-transdermal-drug-delivery-system/?view=fulltext
High molecular weight from 8000 to 12000 leads in a very uncertain rate of delivery. 1; Advantages over Other Drug Delivery System: When compared with injections, this iontophoretic process: Avoid the pain and invasion. Reduces the needle-pricking accidents. Permit its drug delivery by skin contact itself. Can be used outside the hospitals also.
https://www.sciencedirect.com/science/article/pii/S0928098718305268
Taken together, and from a practical point of view, the results reported – assuming their validation in vivo – suggest that iontophoresis of midazolam is perhaps best suited for term and premature neonates with at least a half-competent skin barrier, such that drug delivery is rate-controlled by the current applied (and with due attention to continued input of the drug post-application).Author: Asma Djabri, Richard H. Guy, M. Begoña Delgado-Charro
https://healthjade.com/iontophoresis/
In a randomized, double-blind study comparing iontophoresis of lidocaine/epinephrine with that of placebo, erythema at the site of iontophoresis was observed in about 50% of adults and in 60% of children, whatever the group. In most cases, it was mild, but …
https://www.sciencedirect.com/topics/neuroscience/iontophoresis
Denet et al. reported lowered transdermal delivery of the hydrophobic drug timolol with iontophoresis and electroporation combination than with iontophoresis alone [80]. The decreased transport was explained as being due to an accumulation of positively charged timolol in the SC, which was amplified by electroporation, and a resulting decrease of electroosmotic flux during iontophoresis [44,80] .
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