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https://www.researchgate.net/publication/236641080_Investigating_polymer_thiolation_in_gene_delivery
Investigating polymer thiolation in gene delivery Article (PDF Available) in Journal of Biomaterials Science Polymer Edition 24(8):912-26 · June 2013 with 122 Reads How we measure 'reads'
https://www.tandfonline.com/doi/abs/10.1080/09205063.2012.727266
May 07, 2013 · Thiolated polymers containing disulfide linkages are commonly researched in gene delivery with the assumption that the thiolated complexes form disulfide bonds. This study investigates the extent of disulfide linking in a thiol-containing polymer and determines the impact that free thiols have on the polymer’s delivery potential.Author: Irene Bacalocostantis, Viraj P. Mane, Addison S. Goodley, William E. Bentley, Silvia Muro, Peter Kof...
https://drum.lib.umd.edu/bitstream/handle/1903/13017/Bacalocostantis_umd_0117E_13354.pdf;sequence=1
ABSTRACT Title of Document: INVESTIGATION OF THIOLATED POLYMER IN GENE DELIVERY Irene Bacalocostantis Directed By: Professor Peter Kofinas, Fischell Department of Bioengineering Thiol-containing bioreducible polymers show significant potential as delivery vectors in gene therapy, a rapidly growing field which seeks to treat genetic-based
https://pubs.acs.org/doi/abs/10.1021/bm3004786
Polymers have attracted much attention as potential gene delivery vectors due to their chemical and structural versatility. However, several challenges associated with polymeric carriers, including low transfection efficiencies, insufficient cargo release, and high cytotoxicity levels have prevented clinical implementation. Strong electrostatic interactions between polymeric carriers and DNA ...Author: Irene Bacalocostantis, Viraj P. Mane, Michael S. Kang, Addison S. Goodley, Silvia Muro, Peter Kofina...
https://www.sciencedirect.com/science/article/pii/S0378517314008680
Jan 15, 2015 · The transfection efficiency of PAGs was dependent on the polymer architecture; PAG20, the polymer with the highest buffering capacity, showed the highest ability in gene delivery. The polyplexes made with this polymer were routed via early and late endosomes, inside which the buffering capacity of PAG20 caused swelling of these organelles and ...Author: Magdalena Wytrwal, Magdalena Wytrwal, Chloe Leduc, Michal Sarna, Cristine Goncalves, Mariusz Kepczyn...
https://www.polysciences.com/default/catalog-products/monomers-polymers/polyallyl-amine-mw15000/
Water soluble cationic polymer with primary amino groups (free base types) for chemical reactions. High cationic charge density in ready to use aqueous solution form. The structure of these materials is a repeating polymer of the allyl amine group shown at right. Ability to modify surfaces and provide cationic character allows the user to selectively attract negatively charged functional ...
https://bioe.umd.edu/clark/faculty/89/William-E-Bentley
BACKGROUND. William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering.
https://www.sciencedirect.com/science/article/pii/S0378517318308196
Jan 10, 2019 · Gelatin is a polyelectrolyte with a low-charge density that is appreciably changed depending on the solution’s pH. As a result, the cationization of gelatin is a significant factor in enhancing the ability of the polymer to interact with negatively charged cellular membranes or DNA, thereby obtaining an effective gene delivery vector (Zwiorek et al., 2004).Author: Osama Madkhali, Osama Madkhali, George Mekhail, George Mekhail, Shawn D. Wettig
https://www.researchgate.net/profile/Silvia_Muro
Investigating polymer thiolation in gene delivery. ... Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes. ... University of Maryland, College Park;
https://bioe.umd.edu/clark/faculty/159/Peter-Kofinas
Philip Merrill Presidential Scholars Program Mentor 2014-2015, Office of Undergraduate Studies, U. of Maryland; Engaged Faculty Award 2011, A. James Clark School of Engineering, U. of MarylandOccupation: Chbe Professor And Chair
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