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https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)32258-4.pdf
CD47 is not only observed in leukemia,18 but also in some solid tumors.19 In these tumors, the CD47 expression level could be considered an adverse prognostic factor.19 In vitro delivery of siRNA targeting CD47 in LPH-NPs silences the target gene in B16F10 cells siRNA against CD47 was encapsulated into LPH-NPs through aFile Size: 2MB
https://www.ncbi.nlm.nih.gov/pubmed/23774794
Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis. Wang Y(1), Xu Z, Guo S, Zhang L, Sharma A, Robertson GP, Huang L.Author: Yuhua Wang, Zhenghong Xu, Shutao Guo, Lu Zhang, Arati Sharma, Gavin P Robertson, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808133/
In vitro delivery of siRNA targeting CD47 in LPH-NPs silences the target gene in B16F10 cells. siRNA against CD47 was encapsulated into LPH-NPs through a stepwise, self-assembly process based on a well-established protocol. 20 Briefly, the core of the NP was formed by mixing negatively charged siRNA/hyaluronic acid and positively charged protamine at certain ratio so that the complex was ...Author: Yuhua Wang, Zhenghong Xu, Shutao Guo, Lu Zhang, Arati Sharma, Gavin P Robertson, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S1525001616322584
In the present study, we first examined the CD47 expression level in clinical human melanoma samples. With the confirmation of overexpression of CD47 in the melanoma, we hypothesized that the anti-phagocytic signal could be blocked by knockdown of CD47 with siRNA targeting CD47, which was systemically delivered using LPH-NPs.Author: Yuhua Wang, Zhenghong Xu, Shutao Guo, Lu Zhang, Arati Sharma, Gavin P Robertson, Leaf Huang
https://www.researchgate.net/profile/Shutao_Guo/publication/239944542_Intravenous_Delivery_of_siRNA_Targeting_CD47_Effectively_Inhibits_Melanoma_Tumor_Growth_and_Lung_Metastasis/links/0a85e534687b55dcea000000.pdf
Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis Yuhua Wang1, Zhenghong Xu 1, Shutao Guo , …
https://www.researchgate.net/publication/239944542_Intravenous_Delivery_of_siRNA_Targeting_CD47_Effectively_Inhibits_Melanoma_Tumor_Growth_and_Lung_Metastasis
Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis Article (PDF Available) in Molecular Therapy 21(10) · June 2013 with 296 Reads
https://pennstate.pure.elsevier.com/en/publications/intravenous-delivery-of-sirna-targeting-cd47-effectively-inhibits
title = "Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis", abstract = "CD47 is a {"}self marker{"} that is usually overexpressed on the surface of cancer cells to enable them to escape immunosurveillance.Author: Yuhua Wang, Zhenghong Xu, Shutao Guo, Lu Zhang, Arati Sharma, Gavin P Robertson, Leaf Huang
https://www.scientificarchives.com/article/targeting-do-not-eat-me-signal-cd47-in-cancer-immunotherapy
Further, delivery of liposome loaded anti- CD47 siRNAs inhibited the melanoma growth in mice . Interestingly, CD47-targeting siRNAs showed decreased accumulation of M2 macrophages leading to reduced migration of colon cancer cells . However, the poor uptake, low bioavailability, and off-target effects limit the efficacy of gene silencing ...Author: Sachin Kumar Deshmukh
http://europepmc.org/articles/PMC3808138
Oct 01, 2013 · To the editor: We have read with interest the report by Wang et al. 1 in this issue, “Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis,” describing the targeting of CD47 in melanoma with short interfering RNA (siRNA). In a well-designed series of experiments, the investigators show that both in vitro and in vivo delivery to ...
https://melanoma.org/legacy/find-support/patient-community/mpip-melanoma-patients-information-page/sirna-targeting-cd47
Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis. Yuhua Wang1, Zhenghong Xu1, Shutao Guo1, Lu Zhang1, Arati Sharma2,3,4,5, Gavin P Robertson2,3,4,5 and Leaf Huang1.
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