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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133369/
Given that IL-1 is a key mediator of neuropathic pain, developing a clinically viable means of long-term delivery of IL-10 to the spinal cord is desirable. High doses of intrathecal IL-10-gene therapy using naked plasmid DNA (free pDNA-IL-10) is effective, but the dose required limits its potential clinical utility.Author: Erin D. Milligan, Ryan G. Soderquist, Stephanie M. Malone, John H. Mahoney, Travis S. Hughes, Stephe...
https://www.cambridge.org/core/journals/neuron-glia-biology/article/intrathecal-polymerbased-interleukin10-gene-delivery-for-neuropathic-pain/19680C1A420EE34C1CA9C5B1D4D20DED
Given that IL-1 is a key mediator of neuropathic pain, developing a clinically viable means of long-term delivery of IL-10 to the spinal cord is desirable. High doses of intrathecal IL-10-gene therapy using naked plasmid DNA (free pDNA-IL-10) is effective, but the dose required limits its potential clinical utility.Author: Erin D. Milligan, Ryan G. Soderquist, Stephanie M. Malone, John H. Mahoney, Travis S. Hughes, Stephe...
https://www.researchgate.net/publication/5768564_Intrathecal_polymer-based_interleukin-10_gene_delivery_for_neuropathic_pain
Here we show that intrathecal gene therapy for neuropathic pain is improved sufficiently using two, distinct synthetic polymers, poly(lactic-co-glycolic) and polyethylenimine, that substantially...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443506/
The Sensitization Period. In studies to date, intrathecal delivery of naked pDNA encoding the IL-10 gene (pDNA-IL-10) produces prolonged reversal of neuropathic pain [72, 78, 79]. While intrathecal gene therapy to treat neuropathic pain is not unique [80-86], non-viral pDNA-IL-10 gene delivery is a more recent and novel approach.Author: Erin D. Milligan, Kathryn R. Penzkover, Ryan G. Soderquist, Melissa J. Mahoney
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839806/
Nov 21, 2013 · A range of approaches has been utilized in order to enhance the expression of spinal IL-10 as a therapeutic strategy for the reversal of neuropathic pain.105 The direct intrathecal administration of recombinant IL-10 protein is able to transiently reverse (for a matter of hours) neuropathic pain behaviors induced by peripheral nerve injury, largely due to the short half-life of IL-10 …Author: Anna K Clark, Elizabeth A Old, Marzia Malcangio
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604983/
Jun 01, 2010 · Systemic administration of IL-10 as a treatment for neuropathic pain is not feasible as it is too large to cross the blood-brain barrier. Direct intrathecal IL-10 administration is a viable option, but is not efficacious for a prolonged period due to its rapid clearance (t 1/2 ~2 h…Author: Ryan G. Soderquist, Erin D. Milligan, Jacqueline A. Harrison, Raymond A. Chavez, Kirk W. Johnson, Li...
https://www.sciencedirect.com/science/article/pii/S0889159117305056
Studies show that spinal (intrathecal; i.t.) interleukin-10 (IL-10) gene therapy reverses neuropathic pain in animal models, and co-administration with the mannose receptor (MR; CD206) ligand d-mannose (DM) greatly improves therapeutic efficacy.Author: Arden G. Vanderwall, Shahani Noor, Melody S. Sun, Jacob E. Sanchez, Xuexian O. Yang, Lauren L. Jantz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068128/
PEI complexation has been shown to reduce intrathecal gene delivery requirements by one-half to one-tenth [ 60 – 62 ]. PEI complexation with DNA has also been shown to increase its resultant gene expression in the central nervous system by 10 [ 63] to 40 [ 60] fold after an intrathecal administration.Author: Ryan G Soderquist, Melissa J Mahoney
https://www.researchgate.net/scientific-contributions/38648543_Ryan_G_Soderquist
Use of Interleukin-10-plasmid-DNA as gene therapy alleviates chronic neuropathic pain. Incorporating this DNA into biodegradable microparticles …
https://www.nature.com/articles/srep34356
Sep 27, 2016 · Milligan, E. D. et al. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol 2, 293–308, doi: 10.1017/S1740925X07000488 (2006). ArticleAuthor: Chien-Cheng Liu, Yong-Jing Gao, Yong-Jing Gao, Hao Luo, Temugin Berta, Zhen-Zhong Xu, Zhen-Zhong Xu,...
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