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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854252/
IP drug delivery helps in the regional therapy of these disorders by providing relatively high concentration and longer half-life of a drug in the peritoneal cavity. Various studies suggest that IP delivery of anti-neoplastic agents is a promising approach for malignancies in the peritoneal cavity compared to the systemic administration.Author: Gaurav Bajaj, Yoon Yeo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494136/
May 15, 2015 · In line with our finding, intraperitoneal delivery of Taxol ® has been shown to be efficacious in clinical trials [24,25]. However the dose-limiting toxicity of Taxol ® by intraperitoneal delivery, was severe abdominal pain, likely caused by the excipients (Cremophor EL and ethanol) that are required to overcome low drug solubility . As such ...Author: Yao-An Shen, Wai-Hou Li, Po-Hung Chen, Chun-Lin He, Yen-Hou Chang, Chi-Mu Chuang
https://en.wikipedia.org/wiki/Intraperitoneal_injection
Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity). It is more often applied to animals than to humans. In general, it is preferred when large amounts of blood replacement fluids are needed or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection.
https://clinicaltrials.gov/ct2/show/NCT03213964
Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Int The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
https://www.sciencedirect.com/science/article/pii/S1549963416300454
Mesoporous silica nanoparticles (MSNs) containing paclitaxel for intraperitoneal (i.p.) delivery were developed to exploit the tumor specific accumulation of these nanocarriers after i.p. injection and the slow release of paclitaxel from the MSNs.Author: Qiang Fu, Derek Hargrove, Xiuling Lu
https://journals.lww.com/anesthesia-analgesia/Fulltext/2017/02000/Intraperitoneal_Instillation_of_Lidocaine_Improves.29.aspx
Intraperitoneal instillation of local anesthetic has been shown to be effective in reducing postoperative pain after abdominal surgery. We sought to investigate the effect of intraperitoneal instillation of lidocaine on postcesarean delivery pain as part of a multimodal analgesia regimen. METHODS:
https://www.nature.com/articles/srep30696
Aug 04, 2016 · In this study, three different MSCs delivery routes, intraperitoneal injection (IP), intravenous injection (IV) and anal injection (AI) were compared …Author: Min Wang, Min Wang, Cong Liang, Hao Hu, Lin Zhou, Bing Xu, Xin Wang, Ying Han, Yongzhan Nie, Shuyun ...
https://drc.bmj.com/content/6/1/e000560
Nov 01, 2018 · Intraperitoneal glucagon administration has only been reported from a few animal studies.24 25. The main aim of this study was to compare the glucose increasing effect after subcutaneous and intraperitoneal delivery of glucagon, and to investigate the potential for intraperitoneal delivery of small doses of glucagon in an AP.Author: Ilze Dirnena-Fusini, Marte Kierulf Åm, Anders Lyngvi Fougner, Sven Magnus Carlsen, Sverre Christian ...
https://www.cancernetwork.com/oncology-journal/intraperitoneal-drug-delivery-ovarian-cancer-why-how-who-what-and-when
In 1996, intraperitoneal (IP) administration of cisplatin plus intravenous (IV) cyclophosphamide proved superior to both drugs given intravenously at the same doses—which, at the time, was the standard treatment in the United States.Author: Maria Jose Echarri Gonzalez, Robin Green, Franco M. Muggia
https://www.hindawi.com/journals/tswj/2013/720858/
Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug ...Author: L. De Smet, W. Ceelen, J. P. Remon, C. Vervaet
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