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https://www.researchgate.net/publication/23953065_Intraocular_lens_as_a_drug_delivery_system_for_dexamethasone
To investigate the short-term safety and pharmacokinetic behavior of a new intraocular lens containing a dexamethasone drug delivery system (IOL-DDS) in rabbit eyes.
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-3768.2008.01419.x
Including steroid delivery during a conventional cataract procedure is preferable. Siqueira et al. (2006) evaluated a DDS with a specially designed intraocular lens (IOL) to which a dexamethasone DDS was attached. However, this method allows only one type of IOL, and surgeons prefer a …Author: Maria Kugelberg, Kayvan Shafiei, Ingeborg Van Der Ploeg, Charlotta Zetterström
https://journals.lww.com/co-ophthalmology/Fulltext/2013/01000/Intraocular_lens_as_a_drug_delivery_reservoir.11.aspx
Purpose of review To describe the development and use of intraocular lenses (IOLs) as drug delivery systems and to review the current literature on their application and efficacy.. Recent findings Many drugs have been loaded onto IOLs by coating or by attachment in a separate reservoir.
https://www.drugs.com/cons/dexamethasone-intraocular.html
Jun 14, 2019 · This causes vision changes that must be treated right away. Dexamethasone is also used to treat diabetic macular edema. Dexamethasone intravitreal implant is also used to treat an eye disease called uveitis (swelling in the middle part of the eye). Dexamethasone injection is used to treat inflammation of the eye that may occur after eye surgery.7.4/10
https://clinicaltrials.gov/ct2/show/NCT01602068
May 18, 2012 · The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery System (EGDS) compared to placebo in patients undergoing cataract surgery with implantation of a posterior chamber intraocular lens.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306122/
Dec 26, 2010 · To overcome the above mentione d limitations, an increasing number of sustained-release drug delivery devices using different mechanisms and containing a variety of agents have been developed to treat uveitis. This article reviews major drug delivery technologies currently in clinical trials or at experimental stages for treatment of uveitis.Author: Nahid Haghjou, Masoud Soheilian, Mohammad Jafar Abdekhodaie
http://www.aetna.com/cpb/medical/data/700_799/0795.html
Ozurdex (dexamethasone intravitreal implant) is an intravitreal implant containing 0.7 mg (700 μg) dexamethasone in the Novadur solid polymer drug delivery system. Ozurdex is preloaded into a single‐use, specially designed DDS applicator to facilitate injection of the rod‐shaped implant directly into the vitreous of the eye.
https://www.sciencedirect.com/science/article/abs/pii/S0886335003009209
The Surodex group had the dexamethasone drug delivery system inserted into the anterior chamber (AC) angle during surgery and was treated with saline eyedrops (Isopto Plain ®) for 4 weeks. The control group had no drug delivery system or a placebo inserted at surgery and were treated with dexamethasone 0.1% eyedrops for 4 weeks.Author: Azfar C Wadood, Ana M Armbrecht, Peter A Aspinall, Baljean Dhillon
https://www.changcataract.com/wp-content/uploads/2018/07/Dex_DDS_Paper.pdf
Phase II Results of an Intraocular Steroid Delivery System for Cataract Surgery David F. Chang, MD,1 Ivan H. Garcia, MD,2 John D. Hunkeler, MD,3 Thomas Minas, MD4 Objective: To evaluate the safety and efficacy of an intraocular biodegradable polymer dexamethasone drug delivery system (DEX DDS) in treating postoperative inflammation after cataract surgery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544290/
Phacoemulsification and intraocular lens implantation after inadvertent intracapsular injection of intravitreal dexamethasone implant ... A good surgical outcome with careful phacoemulsification and intraocular lens implantation is possible. ... et al. Randomized controlled study of an intravitreous dexamethasone drug delivery system in ...Author: Ram J, Agarwal Ak, Gupta A
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