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https://www.sciencedirect.com/science/article/pii/S0169409X06001645
Intraocular implants for extended drug delivery: Therapeutic applications ☆ 1. Introduction. The eye is the organ of choice for the practical implantation or injection... 2. Description of the polymers used for intraocular drug delivery implants. 3. Therapeutic applications of ocular implants. ...Author: J.L. Bourges, C. Bloquel, C. Bloquel, Aurélien Thomas, Aurélien Thomas, F. Froussart, F. Froussart, ...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X06001645
Nov 15, 2006 · An overview of ocular implants with therapeutic application potentials is provided. Various types of implants can be used as slow release devices delivering locally the needed drug for an extended period of time. Thus, multiple periocular or intraocular injections of the drug can be circumvented and secondary complications minimized.Author: J.L. Bourges, C. Bloquel, C. Bloquel, Aurélien Thomas, Aurélien Thomas, F. Froussart, F. Froussart, ...
https://www.researchgate.net/publication/6689510_Intraocular_implants_for_extended_drug_delivery_Therapeutic_applications
Intraocular drug delivery systems allow the release of the drug, bypassing the blood-ocular barrier. The main advantage of these preparations is that they can release the drug over a long time ...
https://www.assignmentpoint.com/science/medical/intraocular-implants-for-extended-drug-delivery.html
Intraocular implants for drug delivery are capable of bypassing the barriers to intraocular drug absorption and avoid frequent procedures required using intravitreal injection therapy. Drug release rates of implants can be controlled so that therapeutic drug levels are maintained in the eye, while avoiding toxic or subtherapeutic levels.
https://archive-ouverte.unige.ch/unige:80614
An overview of ocular implants with therapeutic application potentials is provided. Various types of implants can be used as slow release devices delivering locally the needed drug for an extended period of time. Thus, multiple periocular or intraocular injections of the drug can be circumvented and secondary complications minimized.
https://www.ondrugdelivery.com/biodegradable-implants-sustained-intraocular-delivery-small-large-molecules/
EyeLief™ is a preformed implant (Figure 2) that can be administered intraocularly to achieve sustained delivery of a wide range of drug molecules. Being photosensitive, the implant can be selectively crosslinked so as to achieve the desired release rates over an extended period.
https://www.ondrugdelivery.com/wp-content/uploads/2018/02/ONdrugDel-OPHTHALMIC-DRUG-DEL-82-Jan-2018-Re-Vana.pdf
BIODEGRADABLE IMPLANTS FOR SUSTAINED INTRAOCULAR DELIVERY ... delivery of therapeutic proteins in treating back of the eye diseases or frequent eye ... advanced polymeric drug delivery systems for ocular applications. He has authored over …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598676/
Therefore, a tunable implant that allows for control over the delivery of medication is advantageous to avoid unnecessary delivery of the drug. This type of device would also be advantageous because uveitis is a relapsing and remitting disease and it would be attractive to be able to control the drug concentration depending on the disease state [ 110 ].Author: Darren J. Lee
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300024
Intraocular implants are controlled drug delivery systems prepared from biodegradable or non-biodegradable polymers. Generally, these are introduced into the vitreous through an incision in the ocular pars plana, which is located posterior to the lens and anterior to the retina. Despite the invasive characteristics of the implantation technique, the implants present several advantages that outweigh the inconveniences of the implantation procedure.
http://www.mavery.com/academic/Intraocular_DDS.pdf
Also for specific cases, both methods have other negative side effects. These are discussed below in a case study of the development of treatment of cytomegalovirus retinitis. Clinical treatment of the disease progressed from intravenous to intravitreal drug delivery, and finally to an intraocular drug deliver device.
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