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https://www.researchgate.net/publication/50364903_Intraocular_Delivery_of_Recombinant_Virus
Intraocular Delivery of Recombinant Virus. ... following systemic but not intraocular Epo delivery, morphological photoreceptor protection was observed in the light-damage and rds/peripherin ...
https://link.springer.com/protocol/10.1385%2F1-59259-085-3%3A125
In the past 5 yr, advances in technology have been made that allow efficient somatic transfer of functional genes to target cells in the eye in vivo. The ability to deliver functional genes to these...Author: Fong-Qi Liang, Vibha Anand, Albert M. Maguire, Jean Bennett
https://www.ncbi.nlm.nih.gov/pubmed/12756418
Here, the biology of and immune responses to intraocular injection of three different recombinant viral vectors - adenovirus, adeno-associated virus (AAV), and lentivirus - are summarized. Perhaps, in part because of the unique immunological environment of the eye, the immunological effects of these viruses appear to be fairly benign.Author: J Bennett
https://www.nature.com/articles/3302030
May 20, 2003 · Evaluation of the humoral response to adenovirus after intraocular delivery in mice has shown that this virus can induce a systemic humoral response that is suppressed, in comparison to the ...Author: J Bennett
https://www.sciencedirect.com/science/article/pii/S1525001606000815
Proof-of-concept studies in canine and murine animal models of RPE65 (retinal pigment epithelium-specific protein 65 kDa)-deficient Leber congenital amaurosis (LCA), an autosomal recessive human retinal disorder 1, 2, demonstrate restoration of vision to blind eyes by subretinal delivery of RPE65-expressing recombinant adeno-associated virus ...Author: Samuel G. Jacobson, Gregory M. Acland, Gustavo D. Aguirre, Tomas S. Aleman, Sharon B. Schwartz, Artu...
https://www.sciencedirect.com/topics/immunology-and-microbiology/recombinant-virus
Recombinant virus vaccination. A variety of recombinant viruses have been used for therapeutic vaccination in animal studies. Intramuscular injection of a recombinant adenovirus expressing HPV16-E5 reduced growth of TC-1 tumor cells in mice (Liu et al., 2000a).
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(06)00081-5
AAV2 delivery of the RPE65 gene to the retina of blind RPE65-deficient animals restores vision. This strategy is being considered for human trials in RPE65-associated Leber congenital amaurosis (LCA), but toxicity and dose efficacy have not been defined. We studied ocular delivery of AAV-2/2.RPE65 in RPE65-mutant dogs. There was no systemic toxicity. Ocular examinations showed mild or moderate ...Author: Samuel G. Jacobson, Gregory M. Acland, Gustavo D. Aguirre, Tomas S. Aleman, Sharon B. Schwartz, Artu...
https://en.wikipedia.org/wiki/Adeno_associated_virus_and_gene_therapy_of_the_human_retina
In retinal gene therapy, the most widely used vectors for ocular gene delivery are based on adeno-associated virus. The great advantage in using adeno-associated virus for the gene therapy is that it poses minimal immune responses and mediates long-term transgene expression in a variety of retinal cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459107/
Feb 07, 2019 · In this secondary analysis of a clinical trial that included 15 patients, systemic immune responses to recombinant adeno-associated virus 2 were transient and consistent with previous observations reported in the literature. Humoral or cellular immune responses were not associated with adverse events of intraocular inflammation.Author: Céline Bouquet, Catherine Vignal Clermont, Anne Galy, Serge Fitoussi, Laure Blouin, Marion R. Munk, ...
https://www.researchgate.net/publication/10752558_Immune_response_following_intraocular_delivery_of_recombinant_viral_vectors
Immune response following intraocular delivery of recombinant viral vectors Article · Literature Review in Gene Therapy 10(11):977-82 · July 2003 with 14 Reads How we measure 'reads'
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