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https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
(2012) Drug development of intranasally delivered peptides. Therapeutic Delivery 3(4), 557-568 Dhuria SV, Hanson LR, Frey WH, 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99(4), 1654-1673 Merkus FW, Van Den Berg MP (2007) Can nasal drug delivery
https://med.umkc.edu/docs/em/Intranasal_drug_delivery.pdf
Intranasal drug delivery - General principles The nasal cavity's easily accessible, rich vascular plexus permits topically administered drugs to rapidly achieve effective blood levels while avoiding intravenous catheters. This is most effectively accomplished by distributing drug solutions as a mist rather than as larger droplets which may
https://www.researchgate.net/publication/49601002_Nasal_drug_delivery_system_-_an_overview
Nasal drug delivery system - an overview Article (PDF Available) in International Journal of Research in Pharmaceutical Sciences 1(4) · January 2010 with 22,974 Reads How we measure 'reads'
https://www.researchgate.net/publication/49840496_Nasal_Drug_Delivery_in_Humans
Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic). Nasal application circumvents gastrointestinal degradation and hepatic first-pass metabolism of the drug.
https://en.wikipedia.org/wiki/Nasal_administration
If a fast effect is desired or if the drug is extensively degraded in the gut or liver, drugs which are poorly absorbed orally can also be given by this route. Limitations with nasal systemic drug delivery. Nasal administration is primarily suitable for potent drugs since only a …
https://www.sciencedirect.com/science/article/pii/S002432051730663X
The extracellular pathway of intranasal drug delivery begins with crossing the nasal epithelia through the paracellular cleft, navigating tight-junctions (TJ) in the process . Paracellular movement between olfactory neurons and supporting cells allows materials to move from the nasal cavity to the lamina propria . The nasal epithelium, like all ...Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
https://www.sciencedirect.com/science/article/abs/pii/S002432051730663X
The intranasal route is composed of two pathways, one being intracellular while the other being extracellular. The intracellular pathway begins with endocytosis by olfactory sensory cells, followed by axonal transport to their synaptic clefts in the olfactory bulb where the drug is exocytosed.Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
http://www.ajnmmi.us/files/ajnmmi0108227.pdf
Intranasal (IN) delivery is a promising alterna-tive to systemic administration that uses the direct anatomic pathway between the olfacto-ry/trigeminal neuroepithelium of the nasal mucosa and the brain. Since only small amounts of a drug are delivered to the brain using this route, the mechanism of delivery
https://www.slideshare.net/kawii/nasal-drug-delivery-system-41893460
Nov 22, 2014 · INTRODUCTION Administration of drug through nasal route is referred as Nasal drug delivery system. Nasal route is an alternative to invasive administrations and provides a direct access to the systemic circulation. Intranasal Medication administration offers a …
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