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https://www.sciencedirect.com/science/article/pii/S0361923018303678
The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challenging from several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism, elimination, the unwanted side effects and also the high dose to be added mean both inconvenience for the patients and high costs for the patients, their family and the society.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.sciencedirect.com/science/article/pii/S0378517319303862
The systems not only deliver small synthetic drugs, but also large molecules, such as protein or peptides, hormones, and stem cells, to obtain a therapeutic benefit. Nanotechnology based delivery system is the current highlight of intranasal drug delivery targeting the brain.Author: Bappaditya Chatterjee, Bapi Gorain, Keithanchali Mohananaidu, Pinaki Sengupta, Uttam Kumar Mandal, H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · 1.1. Chalenges in CNS Drug Delivery. Drug delivery technologies such as liquid, semi-solid or particulate formulations are important to deliver pharmaceutical compounds safely to their desired site of therapeutic activity [].A highly critical point in drug delivery is the low availability of drugs in the central nervous system (CNS) due to the blood-brain barrier.Author: Stella Gänger, Katharina Schindowski
https://www.researchgate.net/publication/7464235_Intranasal_Drug_Delivery_for_Brain_Targeting
Intranasal drug delivery is one of the focused delivery options for brain targeting, as the brain and nose compartments are connected to each other via the olfactory route and via peripheral ...
http://www.eurekaselect.com/61069/article
Many advanced and effective approaches to brain delivery of drugs have emerged in recent years. Intranasal drug delivery is one of the focused delivery options for brain targeting, as the brain and nose compartments are connected to each other via the olfactory route and via peripheral circulation.
http://www.thepharmajournal.com/vol2Issue1/Issue_march_2013/14.pdf
olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field. Keyword: Nasal Delivery, Brain targeting, Blood-Brain barrier (BBB ...
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
10. Vyas TK, Shahiwala A, Marathe S, Misra A. Intranasal drug delivery for brain targeting. Curr Drug Deliv. 2005;2:165-175. 11. Mygind N, Dahl R. Anatomy, physiology and function of the nasal cavities in health and disease. Adv Drug Deliv Rev.1998;29(1):3-12. 12. Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous ...
https://www.academia.edu/4126530/Intranasal_Drug_Delivery_for_Brain_Targeting
Intranasal Drug Delivery for Brain Targeting
http://www.eurekaselect.com/61069
Many advanced and effective approaches to brain delivery of drugs have emerged in recent years. Intranasal drug delivery is one of the focused delivery options for brain targeting, as the brain and nose compartments are connected to each other via the olfactory route and via peripheral circulation.Author: Tushar K. Vyas, Aliasgar Shahiwala, Sudhanva Marathe, Ambikanandan Misra
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