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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044245/
Mar 01, 2011 · Delivery of vaccine antigens to the dermis and/or epidermis of human skin (i.e. intradermal delivery) might be more efficient than injection into the muscle or subcutaneous tissue, thereby reducing the volumes of antigen.Author: JK Hickling, KR Jones, M Friede, D Zehrung, D Chen, D Kristensen
https://www.ncbi.nlm.nih.gov/pubmed/21379418
Mar 01, 2011 · Delivery of vaccine antigens to the dermis and/or epidermis of human skin (i.e. intradermal delivery) might be more efficient than injection into the muscle or subcutaneous tissue, thereby reducing the volumes of antigen. This is known as dose-sparing and has been demonstrated in clinical trials with some, but not all, vaccines.Author: JK Hickling, KR Jones, M Friede, D Zehrung, D Chen, D Kristensen
https://www.who.int/immunization/programmes_systems/supply_chain/optimize/Intradermal-delivery-vaccines_report_2009-Sept.pdf
Intradermal Delivery of Vaccines 1. Introduction The vast majority of vaccines are delivered intramuscularly (IM) or subcutaneously (SC) using a needle and syringe (N&S). Intradermal delivery (IDD) has been and is being used as the route of choice for only a very
https://www.hindawi.com/journals/jir/2019/8303648/
Intradermal immunization for vaccine delivery is an upcoming strategy showing significant advantages over conventional vaccination routes. In particular, in the last few years, intradermal vaccination has gained momentum as an alternative and more effective vaccine delivery route, both from a scientific and a commercial point of view (Table 3 ).Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.sciencedirect.com/science/article/pii/S0264410X17307958
Intradermal vaccine delivery is a promising alternative to the conventional intramuscular route. The skin layer is immunologically supported by a densely network of antigen presenting cells, while the skeletal muscle is loaded with a relatively sparse population of APCs. Nevertheless, the vaccine to be suitable for intradermal delivery needs...Author: Agnese Donadei, Cristiana Balocchi, Maria R. Romano, Luigi Panza, Roberto Adamo, Francesco Berti, De...
https://novosanis.com/intradermal-injection
Intradermal jet injectors have been used in mass vaccination projects, or as an alternative for insulin injection for diabetic patients. However, sometimes small amounts of vaccine do not enter the skin, but “splash back” from the device, often alarming both patient and administrator (1) .
https://www.nature.com/articles/s41467-019-08852-4
Feb 20, 2019 · Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. ... Previous studies have demonstrated the feasibility of mRNA delivery for vaccination …Author: Li-Ming Gan, Li-Ming Gan, Li-Ming Gan, Maria Lagerström-Fermér, Leif G. Carlsson, Cecilia Arfvidsson...
https://www.cdc.gov/flu/professionals/vaccines.htm
If the vaccine recipient sneezes immediately after administration, the dose should not be repeated. If nasal congestion is present that might interfere with delivery of the vaccine to the nasopharyngeal mucosa, deferral should be considered, or another age appropriate vaccine should be administered.
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