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https://www.sciencedirect.com/science/article/pii/B9780323401968000760
Bupivacaine and clonidine are both well supported as adjuncts in mixed intrathecal infusions but not as sole agents. Corticosteroids are weakly supported for use in postherpetic neuralgia. Potential complications of intrathecal drug delivery can be related to medications or their delivery systems and must be considered when initiating this therapy.Author: David E. Jamison, Steven P. Cohen, Joshua Rosenow
https://link.springer.com/chapter/10.1007/978-1-4612-1938-5_21
Our increasing knowledge of pain mechanisms now makes it clear that cutting the peripheral or central nervous system does not simply stop an input from reaching the brain. 1 Keywords Cancer Pain Salmon Calcitonin Epidural Morphine Intrathecal Morphine Intractable PainAuthor: Robert M. Levy, Damon Salzman
https://global.medtronic.com/xg-en/patients/treatments-therapies/drug-pump-chronic-pain/what-to-expect/implant.html
RISKS OF TARGETED DRUG DELIVERY. Pump or catheter problems can occur after implantation, which may require corrective surgery and/or cause a drug overdose or underdose that may be serious or life-threatening. Implanting the system has risks similar to any surgical procedure…
https://www.researchgate.net/publication/287408608_Implanted_drug_delivery_systems_for_the_control_of_chronic_pain
The INFUSAID model #400 totally implantable drug delivery system was implanted in 17 patients for the continuous infusion of spinally administered preservative-free morphine sulfate.
https://www.webmd.com/pain-management/qa/what-are-the-two-types-of-surgical-implants-that-help-chronic-pain
Oct 18, 2019 · When surgical implants are used to control pain, which is rare, there are two main types: Intrathecal drug delivery. This is also called an infusion pain pump or a spinal drug delivery system that gets medication directly into the intrathecal space around the spinal cord. Spinal cord stimulation implants.
https://www.webmd.com/pain-management/guide/spinal-drug-delivery-systems
Pain relief through spinal drug delivery systems, also called intrathecal drug delivery systems, involves implanting a small pump or using a catheter that delivers medication directly to the spinal cord, where pain signals travel. In many cases, spinal drug delivery systems are used to treat people who have cancer pain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761861/
Jan 29, 2016 · Intrathecal drug delivery systems can be used to manage refractory or persistent chronic nonmalignant (noncancer) pain. We investigated the benefits, harms, cost-effectiveness, and budget impact of these systems compared with current standards of care for adult patients with chronic pain owing to nonmalignant conditions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786068/
Intrathecal drug delivery systems represent an important component of interventional strategies for refractory chronic pain syndromes. Continuous intrathecal administration of opioids results in higher subarachnoid drug concentrations, improved pain scores, and less frequent side effects when compared with systemic opioid administration.Author: Robert Bolash, Belinda Udeh, Youssef Saweris, Maged Guirguis, Jarrod E. Dalton, Natalya Makarova, Na...
https://www.spine-health.com/treatment/pain-management/spinal-cord-stimulators-and-pain-pumps-implantable-systems-neuropathy
Medication is delivered directly to the spinal cord when an intrathecal pain pump is implanted. Sending medication to the pain receptors near the spine interrupts pain signals to the brain, easing the perception of pain. To begin the procedure, the person is placed under local or general anesthesia.
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