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https://www.sciencedirect.com/topics/medicine-and-dentistry/intracoronary-drug-administration
Intracoronary Delivery. Intracoronary infusion has been the most popular mode of stem cell delivery in the clinical setting, especially after AMI. The intracoronary delivery of stem cells has been shown to be safe at 4–9 days after an AMI in the clinical setting [10–16].
https://www.ahajournals.org/doi/10.1161/01.CIR.92.9.2463
The drug-delivery device could be placed and inflated at the lesion site in all cases. No acute complications occurred during intracoronary coil balloon insertion, prolonged deployment, or retrieval in the guiding catheter. Angiographically, in 22 patients, the MLD of the treated lesions was 1.07±0.40 mm at diagnostic angiography.Author: Edoardo Camenzind, Peter-Paul Kint, Carlo Di Mario, Jürgen Ligthart, Wim van der Giessen, Eric Boer...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861011/
Intracoronary abciximab using local drug delivery catheter in patients with STEMI with thrombus burden significantly improves TMP grading without increasing the risk of bleeding. This benefit is achieved even in patients without thrombus aspiration.Author: G. Sengottuvelu, V. Ravi Sekar
https://onlinelibrary.wiley.com/doi/full/10.1111/joic.12318
After occurrence of no‐reflow patients were randomized into two groups according to the route of drug delivery to receive adrenaline ± verapamil either through a well‐cannulated guiding catheter (Group 1) or distally through a perfusion balloon or a selective microcatheter (Group 2) with post‐injection assessment of TIMI flow grade 13 and myocardial blush grade (MBG), 14 repeated injections were done in both …Author: Tamer Abu Arab, Ramy Rafik, Adel El Etriby
https://www.ahajournals.org/doi/10.1161/01.CIR.96.1.154
During intracoronary inflation, fluid-mediated pressure in the drug-delivery compartment of the device was recorded through the infusion port, allowing an estimation of the pressure in the drug compartments.Author: Edoardo Camenzind, Willem H. Bakker, Ambroos Reijs, Ingeborg M. van Geijlswijk, Eric Boersma, Michae...
https://www.researchgate.net/publication/12273511_Intracoronary_drug_delivery_Mechanically_too_rough_pharmacologically_too_weak
Four local drug delivery catheters were tested for intracoronary gene transfer efficiency: the Infiltrator (INF, n = 10), the Crescendo (CRE, n = 10), the Infusasleeve (SLE, n = 8), and the Remedy ...
https://onlinelibrary.wiley.com/doi/full/10.1111/joic.12542
Jul 19, 2018 · In a search of Medline and Google Scholar, four publications were found describing intracoronary drug delivery distally through a microcatheter. NTG was administered through a microcatheter in two of these reports, with verapamil and diltiazem in the other two reports. Both drugs were found to be efficient in addressing no reflow.Author: Yakup Balaban, Ahmet Kaya, Mustafa H. Satilmisoglu, Muhammet B. Balaban
https://www.ncbi.nlm.nih.gov/pubmed/7834736
The purpose of this study was to assess a new technique for treating intracoronary thrombus consisting of the local delivery of urokinase directly to the angioplasty site with a novel, catheter-based, drug delivery …Author: Raymond G. McKay, Raymond G. McKay, Daniel B. Fram, Jeffrey A. Hirst, Francis J. Kiernan, Charles A....
https://www.wikidoc.org/index.php/Intracoronary_pharmacotherapy
Intracoronary Pharmacotherapy The main aim of IC pharmacotherapy is to improve and re-establish effective tissue level perfusion, prior to irreversible changes are triggered. Emphasis is to deliver the drug in the highest possible concentration to the affected area thus potentially minimizing systemic effects and ensuring drug delivery to the affected area in coronary slow-flow or no-reflow states.
https://www.fda.gov/drugs/data-standards-manual-monographs/route-administration
Administration of a drug within a portion of a tooth which is covered by enamel and which is separated from the roots by a slightly constricted region known as the neck. I-CORONAL 117
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