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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159727/
Intracochlear drug delivery systems are emerging in response to recent advances in molecular biology and understanding of the mechanisms underlying inner ear diseases, and as a means to overcome many of the barriers and limitations of conventional drug delivery …Author: Jeffrey T Borenstein
https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1444026
Mar 14, 2018 · Schematic of the delivery chip component of an intracochlear drug delivery (ICDD) device comprising microfluidic drug storage and flow control. The ICDD device is connected, via a small tube inserted into the scala tympani, to the basal turn of the human …Author: M. Peppi, A. Marie, C. Belline, J. T. Borenstein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457114/
Intracochlear drug delivery has the potential to greatly enhance efficacy of cochlear implants for the profoundly deaf. Eshraghi demonstrated conservation of hearing by direct scala tympani delivery of dexamethasone for 8 days following electrode insertion trauma induced hearing loss in the guinea pig .Author: David A Borkholder
https://link.springer.com/10.1007/s00106-016-0285-9
Dec 08, 2016 · Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (i. e., through intratympanic injection), intracochlear administration (particularly for gene and stem cell therapy), as well as various combinations with auditory neurosensory prostheses, either evaluated in preclinical or …Author: S. K. Plontke, G. Götze, T. Rahne, A. Liebau
https://www.sciencedirect.com/science/article/pii/S0928098718304226
Jan 01, 2019 · Intracochlear drug delivery (ICDD) entails direct administration of drugs into the cochlear fluids, enabling improved precision over dosing pharmacokinetics and the potential for well-controlled spatiotemporal drug distribution (McCall et al., 2010; Borenstein, 2011).Author: Andrew M. Ayoob, Andrew M. Ayoob, Andrew M. Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jef...
https://www.sciencedirect.com/science/article/abs/pii/S0928098718304226
Measurement of drug distribution in the inner ear has important roles in the design of local delivery methods, such as direct, intracochlear delivery, and in assessment of emerging drug candidates in preclinical animal models.Author: Andrew M. Ayoob, Andrew M. Ayoob, Andrew M. Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jef...
https://journals.lww.com/thehearingjournal/Fulltext/2019/07000/Inner_Ear_Drug_Delivery__Tomorrow_s_Treatment_for.1.aspx
Three administrative routes are employed in inner ear drug delivery: intratympanic, intracochlear, and systemic. Intratympanic administration involves syringe injection to the tympanic membrane (TM), delivering the drug across the middle ear to be absorbed through the round window membrane (RWM) and into the cochlea.
https://www.researchgate.net/publication/51167783_Intracochlear_Drug_Delivery_Systems
The aim of this article is to provide a concise review of intracochlear drug delivery systems currently under development and ultimately capable of being combined with emerging therapeutic ...
http://news.mit.edu/2015/implantable-drug-delivery-microchip-device-0629
Jun 29, 2015 · This dime-sized prototype contained only 34 reservoirs, each controlled by an individual wire connected to an external power source. At the time, they considered a broad range of practical, and somewhat fantastical, applications beyond drug delivery, including disease diagnostics and jewelry that could emit scents.
https://www.researchgate.net/publication/7702796_A_method_for_intracochlear_drug_delivery_in_the_mouse
There are three key requirements for an intracochlear drug delivery system: (1) a high degree of miniaturization (2) a method for pumping precise and small volumes of fluid into the cochlea in a ...
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