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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Another theme that emerges from the intracellular antibody delivery concept is the ability to relocate protein-of-interest within the cells or deplete it through a cellular protein elimination system. Protein relocation is an approach to interfere with target protein function through trapping it with binder molecule and thereby preventing the ...Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.frontiersin.org/articles/10.3389/fphar.2018.01208/full
Oct 24, 2018 · In addition to the physical delivery described above, a well-established straightforward method for intracellular antibody delivery is the so-called intrabody technique. An intrabody is an antibody or its derivative produced within the same cell where the antigen is located.Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.nature.com/articles/s41598-019-55091-0
Dec 10, 2019 · Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions Skip to main content Thank you for visiting nature.com.Author: Julie Gaston, Nicolas Maestrali, Guilhem Lalle, Marie Gagnaire, Alessandro Masiero, Bruno Dumas, Tar...
https://www.sciencedirect.com/science/article/pii/S0165247802001463
3.2. Intracellular delivery of monoclonal anti-Gag antibody. All of the antibodies were tested on all cell lines for cellular penetration prior to modification. With one exception, 3B3, no staining was seen. The fields were essentially blank, i.e not even surface binding could be seen.Author: Bi-Xing Chen, Bernard F Erlanger
https://www.ncbi.nlm.nih.gov/pubmed/28657549
Aug 18, 2017 · Antibody-based drugs have attracted much attention for their targeting ability, high efficacy and low toxicity. But it is difficult for those intrabodies, a kind of antibody whose targets are intracellular biomarkers, to become effective drugs due to the lack of intracellular delivery strategy and their short circulation time in blood.Author: Lipeng Gao, Lin Han, Xiaoling Ding, Jiaojiao Xu, Jing Wang, Jianzhong Zhu, Weiyue Lu, Jihong Sun, Le...
https://clincancerres.aacrjournals.org/content/25/15/4846
Aug 01, 2019 · Experimental Design: We have developed a new targeted nanomedicine based on hyaluronic acid–biocompatible nanocapsules, which allow the intracellular delivery of a specific anti-GSDMB antibody into HER2 breast cancer cells both in vitro and in vivo.Author: Ángela Molina-Crespo, Ana Cadete, David Sarrio, Manuel Gámez-Chiachio, Lidia Martinez, Kinlin Chao, ...
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b01335
Direct intracellular delivery of antibodies has gained much attention, although only a few agents have been developed, and none of them has reached clinical stages. The main obstacles here are the insufficient characteristics of delivery systems including stability and appropriate ability for intracellular antibody release.Author: Ahram Kim, Yutaka Miura, Takehiko Ishii, Omer F. Mutaf, Nobuhiro Nishiyama, Horacio Cabral, Kazunori...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
Aug 18, 2017 · Intracellular Antibodies. Intracellular antibodies, which may also be called intrabodies, are antibodies that are produced in the cell, and bind an antigen within the same cell. This is a different delivery strategy from antibodies that are produced extracellularly, and are engineered to then penetrate the cell to access their intracellular target.Author: Iva Trenevska, Demin Li, Alison H. Banham
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30115-0
May 01, 2015 · Antibodies armed with biologic drugs could greatly expand the therapeutic potential of antibody–drug conjugates for cancer therapy, broadening their application to disease targets currently limited by intracellular delivery barriers. Additional selectivity and new therapeutic approaches could be realized with intracellular protein drugs that more specifically target dysregulated pathways in ...Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
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