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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527479/
The delivery of cytokines as recombinant proteins can result in toxicity and other adverse effects; however the delivery of cytokine genes using EP has been shown to be safe and effective. Interleukin 15 (IL-15) is a cytokine that promotes the innate as well as the adaptive immune response to cancer cells and bacterial pathogens.Author: Bernadette Marrero, Shawna Shirley, Richard Heller
https://stm.sciencemag.org/content/5/201/201ra118.full
Sep 04, 2013 · Antibody-Based Delivery of Interleukin-2 to Neovasculature Has Potent Activity Against Acute Myeloid Leukemia. By Katrin L. Gutbrodt, Christoph Schliemann, Leonardo Giovannoni, Katharina Frey, Thomas Pabst, Wolfram Klapper, Wolfgang E. Berdel, Dario Neri.Author: Katrin L. Gutbrodt, Christoph Schliemann, Leonardo Giovannoni, Katharina Frey, Thomas Pabst, Wolfram...
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1479-3
Apr 30, 2019 · The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro-inflammatory cytokines and reduce apoptosis. Primary limitations when using systemic injections of IL-10 are that it is rapidly cleared from the injury site and that it does not cross the blood–spinal cord barrier. Here ...Author: Daniel J. Hellenbrand, Kaitlyn A. Reichl, Benjamin J. Travis, Mallory E. Filipp, Andrew S. Khalil, D...
https://www.sciencedirect.com/science/article/pii/S0142961219301085
While interleukin-10 (IL-10) is a potent anti-inflammatory and anti-fibrotic cytokine, its utility in treating lung fibrosis has been limited by its short half-life. We describe an innovative hydrogel-based approach to deliver recombinant IL-10 to the lung for the prevention and reversal of pulmonary fibrosis in a mouse model of bleomycin ...Author: Elya A. Shamskhou, Michael J. Kratochvil, Mark E. Orcholski, Nadine Nagy, Gernot Kaber, Emily Steen,...
https://www.ncbi.nlm.nih.gov/pubmed/19009549
Despite the fact that different administration routes and delivery systems have been used for interleukin-2 (IL-2) delivery, little has been reported regarding the most efficient strategies used to deliver IL-2 in a nontoxic, efficient, stable and safe manner.Author: Mohamed A. Shaker, Husam M. Younes, Husam M. Younes
https://academic.oup.com/humrep/article/26/9/2344/721427
Jun 24, 2011 · The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model Kathrin Schwager. 1. Philochem AG, c/o ETH Zurich, Institute of Pharmaceutical Sciences, Wolfgang-Pauli-Str. 10 HCI E520, CH-8093 Zurich, Switzerland. Search for …Author: Kathrin Schwager, Frank Bootz, Patrick Imesch, Manuela Kaspar, Eveline Trachsel, Dario Neri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342945/
Jan 01, 2012 · Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cellsAuthor: Cindy Meyer, Katja Eydeler, Eileen Magbanua, Tijana Zivkovic, Nicolas Piganeau, Inken Lorenzen, Joac...
https://www.labcorp.com/tests/140916/interleukin-6-serum
Interleukin 6 (IL-6) is a pleiotropic cytokine that acts as both a proinflammatory and anti-inflammatory mediator. 1 It is secreted by T cells and macrophages to stimulate immune response (eg, during infection and after trauma, especially burns or other tissue damage leading to inflammation). IL-6 has been shown in mice to be required for resistance against the bacterium Streptococcus pneumoniae.
https://en.wikipedia.org/wiki/Interleukin_6
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
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