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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
BUCCAL INSULIN. Buccal delivery of insulin has similar benefits as oral insulin with the advantage of bypassing GI degradation. Furthermore, the relatively large surface area results in better bioavailability. Initially, Generex Biotechnology developed Oral-lyn™ which is a liquid formulation of short acting insulin that is administered using Generex's metered dosage aerosol applicator (RapidMist™).
http://www.iptonline.com/articles/public/IPT_17_2005_p74_76.pdf
The Buccal Delivery of Insulin A system for the administration of medicines directly into the mouth for absorption by the buccal mucosa is showing promise in the oral delivery of insulin – as well as other large-molecule drugs. By Gerald Bernstein at Generex Biotechnology Corporation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769877/
In this study, buccal insulin will be compared to prandial injections of regular insulin (not rapid-acting insulin analogs); using twice-daily NPH as basal insulin. So the comparator is a more classical insulin therapy.Author: Lutz Heinemann, Yves Jacques
https://journals.sagepub.com/doi/pdf/10.1177/193229680900300323
injections is the use of microneedles for insulin delivery. With intradermal injection or infusion of regular human insulin or a rapid-acting insulin analog, a rapid onset of action along with a meal can be achieved.2 The aim of this review is to critically review our current knowledge about oral insulin and buccal insulin, two other quite
https://www.medscape.com/viewarticle/711237
Nov 04, 2019 · Insulin Delivered by Buccal Spray Shows Promise. October 23, 2009 (Montreal, Quebec) — Twelve puffs per day from a buccal spray unit can help individuals with impaired glucose tolerance (IGT) keep their blood glucose levels down, according to a study presented here at the International Diabetes Federation (IDF) 20th World Diabetes Congress.
https://www.researchgate.net/publication/23221165_Delivery_of_insulin_to_the_buccal_mucosa_utilizing_the_RapidMist_system
Sodium cholate is present in the RapidMist ™ spray that is used for delivery of insulin to the buccal mucosa [84]. Regarding the differential scanning calorimetry (DSC) results of Gandhi et al ...Author: Gerald Bernstein
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