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https://link.springer.com/article/10.1007%2FBF00258302
In this regard serum apparently contains factor(s) that promote the dissolution of insulin and prevent the formation of peptide aggregates in dilute solutions. Many laboratories are now working to resolve the problem of insulin aggregation in artificial delivery devices.Author: W. D. Lougheed, H. Woulfe-Flanagan, J. R. Clement, A. M. Albisser
https://www.ncbi.nlm.nih.gov/pubmed/6771181
1. Diabetologia. 1980 Jul;19(1):1-9. Insulin aggregation in artificial delivery systems. Lougheed WD, Woulfe-Flanagan H, Clement JR, Albisser AM.Author: W. D. Lougheed, H. Woulfe-Flanagan, J. R. Clement, A. M. Albisser
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52720/
Nov 01, 1991 · The stability of protein-based pharmaceuticals (e.g., insulin) is important for their production, storage, and delivery. To gain an understanding of insulin's aggregation mechanism in aqueous solutions, the effects of agitation rate, interfacial interactions, and insulin concentration on the overall aggregation rate were examined.Author: V Sluzky, J A Tamada, A M Klibanov, R Langer
https://www.deepdyve.com/lp/springer-journals/insulin-aggregation-in-artificial-delivery-systems-yB4tElSIrA
In this regard serum apparently contains factor(s) that promote the dissolution of insulin and prevent the formation of peptide aggregates in dilute solutions (41). Many laboratories are now working to resolve the problem of insulin aggregation in artificial delivery devices.
https://diatribe.org/sneak-peek-lillys-automated-insulin-delivery-system
What is automated insulin delivery? Automated insulin delivery, or AID, seeks to use CGM and smart algorithms to decide how much insulin to deliver via pump. Also known as an artificial pancreas, AID’s end goal is to remove user input from insulin dosing, reduce hypoglycemia, and improve time in target range. For more info on AID systems in development, click here.
https://www.nanalyze.com/2019/04/artificial-pancreas-diabetics/
In 2016, the FDA approved the world’s first Hybrid Closed Loop (HCL) insulin delivery system, Medtronic’s MiniMed 670G System, which is intended to automatically monitor blood sugar and adjust basal insulin doses in people with type 1 diabetes. Here’s a look at the slide from Medtronic which shows the evolution of the system going forward as more functionality gets added.
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