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https://www.sciencedirect.com/science/article/pii/S1359644600016007
Jan 15, 2001 · The oral delivery of peptide, protein, vaccine and nucleic acid-based biotechnology products is the greatest challenge facing the drug delivery industry. Oral delivery is attractive due to factors such as ease of administration, leading to improved patient convenience and compliance, thereby reducing overall healthcare costs.Author: David T Page, Sally Cudmore
https://www.ncbi.nlm.nih.gov/pubmed/11166257
Jan 01, 2001 · The oral delivery of peptide, protein, vaccine and nucleic acid-based biotechnology products is the greatest challenge facing the drug delivery industry. Oral delivery is attractive due to factors such as ease of administration, leading to improved patient convenience and compliance, thereby reducing overall healthcare costs. The realization that gene therapy will provide a tangible and potentially huge new therapeutic opportunity has stimulated interest in oral gene delivery.Author: David T Page, Sally Cudmore
https://www.researchgate.net/publication/222880215_Innovations_in_oral_gene_delivery_Challenges_and_potentials
However, the oral route presents distinct challenges and barriers to achieving successful gene delivery. Oral non-viral gene delivery systems must be able to survive the harsh and variable ...
https://www.deepdyve.com/lp/elsevier/innovations-in-oral-gene-delivery-challenges-and-potentials-UslFK0aBFx
Jan 15, 2001 · Innovations in oral gene delivery: challenges and potentials Page, David T; Cudmore, Sally 2001-01-15 00:00:00 The oral delivery of peptide, protein, vaccine and nucleic acid-based biotechnology products is the greatest challenge facing the drug delivery industry. Oral delivery is attractive due to factors such as ease of administration, leading to improved patient convenience and …
https://www.liebertpub.com/doi/abs/10.1089/hum.1994.5.3-323
Innovations in oral gene delivery: challenges and potentials Drug Discovery Today, Vol. 6, No. 2 Adenovirus-mediated human pancreatic lipase gene transfer to rat bile: gene therapy of …Author: James W. Sandberg, Chantal Lau, Mario Jacomino, Milton Finegold, Susan J. Henning
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474414/
Oral Gene Delivery for Gene Therapy Applications Delivery of genetic materials, such as plasmid DNA or siRNA [ 5 – 9 ], as well as combination therapies that deliver both genetic and pharmacological treatments [ 10 ], via the oral route, have been explored for the treatment of several diseases.Author: Eric Farris, Kari Heck, Anna T. Lampe, Deborah M. Brown, Amanda E. Ramer-Tait, Angela K. Pannier
https://www.tandfonline.com/doi/figure/10.1080/1061186X.2019.1630415
In this article, we present an overview of the latest advances in targeted gene delivery and discuss the challenges and future direction of gene therapy in the treatment of neurological disorders. Keywords: Gene therapy , gene delivery , neurological diseases , CRISPER/Cas9 system , viral vectors , non-viral vectors , Autism Spectrum disorderAuthor: Stefanie A. Pena, Rahul Iyengar, Rebecca S. Eshraghi, Nicole Bencie, Jeenu Mittal, Abdulrahman Aljoh...
https://www.sciencedirect.com/science/article/pii/S2468451118300254
Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends itself to high patient compliance and ease of dosing.Author: Eric Farris, Kari Heck, Anna T. Lampe, Deborah M. Brown, Amanda E. Ramer-Tait, Angela K. Pannier
https://link.springer.com/article/10.1007/BF03184167
Jul 01, 2003 · The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system of safety, ease of manufacturing, etc. As important nonviral vectors, polymer gene delivery systems have gained increasing attention and have begun to show increasing promising. In this review, the fundamental and ...Author: Shiwen Huang, Renxi Zhuo
https://www.nature.com/articles/3302635
Sep 15, 2005 · Alternative gene therapy: transformed bacteria produce the therapeutical polypeptide in situ in the cells or in the intercellular space. (a) Transformed bacteria that contain plasmids carrying the transgene are applicated into the target tissue and either enter the cells or stay in the intercellular matrix.Author: R Pálffy, R Gardlík, J Hodosy, M Behuliak, P Reško, J Radvánský, P Celec
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