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https://www.catalent.com/specialty/inhalation/
Engaged with and influential among inhalation expert groups; Integrated preformulation and formulation services; Development across all common dosage forms (MDI, Nebules, Nasal, DPI) Reliably supplied with an exemplary regulatory track record Global project and supply chain management to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The STACCATO ® is a novel breath-actuated inhalation delivery system, which uses heat to vaporize a thin film of the drug, which later condenses in the lungs into droplets or particles depending on the nature of the drug.78 In that case, the drug is dissolved in volatile solvent/solvent mixture which is sprayed over a metal substrate such as ...Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
https://www.ncbi.nlm.nih.gov/pubmed/15737247/
Inhalation is a very old method of drug delivery, and in the 20th century it became a mainstay of respiratory care, known as aerosol therapy. Use of inhaled epinephrine for relief of asthma was reported as early as 1929, in England.Author: Joseph L Rau
https://www.sciencedirect.com/science/article/pii/S1471489217300176
Inhalation offers the opportunity to deliver complex molecules locally and systemically. • Pulmonary insulin works well, but failed to make a commercial impact so far. • Inhaled biomolecules for topical therapy of lung diseases are efficacious. • Several inhaled small …Author: Wilbur de Kruijf, Carsten Ehrhardt
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary Drug Delivery. Pulmonary drug delivery is the inhalation of drug formulation through mouth and the further deposition of inhaled pharmacological agent in lower airways is the main purpose of this drug delivery route.
https://www.mannkindcorp.com/Collateral/Documents/English-US/Innovation%20In%20Drug%20Delivery%20by%20Inhalation.pdf
for inhaled drug delivery. Going forward, systemic delivery by inhalation will have a dramatic impact on the market as more active agents are shown to benefit from this route of administration. However, the real impact will be realised when patients are given the opportunity to self-administer therapies in easy-to-use,
https://www.meddeviceonline.com/doc/what-s-next-in-inhalation-drug-delivery-0001
Jan 10, 2017 · While each device has its own unique combination of device design and drug formulation, all inhalation devices share some common challenges. Drug formulation and aerosolization — Inhalation devices must be thought of as combination products. In fact, inhalation delivery is a three-part system consisting of the user, the device, and the drug.
http://www.pharmtech.com/inhalation-drug-delivery-impact-particle-size-reduction
Sep 02, 2019 · For inhalation delivery, a narrow and controlled particle size distribution (PSD) is key to improving and consistently delivering the aerodynamic performance. With a narrow PSD and Dv90<5µm, the fraction of particles that reach the lungs (FPF) will be higher.
https://www.pnas.org/content/98/20/11103
Sep 25, 2001 · Inhalation of relevant quantities of aerosolized ethanol by itself caused no appreciable acute toxicity. In rats, the bioavailability of insulin delivered via this approach was comparable to those observed in the inhalation delivery of insulin aqueous solutions or conventional dry powders.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
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