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https://www.researchgate.net/publication/8669676_Induction_of_Cell_Death_by_Saponin_and_Antigen_Delivery
Results presented in this study have demonstrated the roles of emulsion adjuvants in induction of cell death and delivery of exogenous antigens for cross-priming, leading to stimulation of antigen ...
https://link.springer.com/article/10.1023/B:PHAM.0000016239.04067.66
Pretreatment of EL4 cells with zVAD-fmk, a broad-range caspase inhibitor, did not prevent cell death induced by saponin, indicating the non-caspase-dependent cell death. Dendritic cells were shown to phagocytose both the antigen-saponin complexes and the saponin-induced dead cells. Conclusions.Author: Ching-An Wu, Ya-Wun Yang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659611/
RG extract and RG saponin have been shown to elevate antigen-specific immune response when they are coinjected with antigen ... from a broad range of plants [11,29]. The saponins induce both the apoptosis and necrosis of immune cells, and the cell death signals are ... Wu CA, Yang YW. Induction of cell death by saponin and antigen delivery. ...Author: Mei Ling Xu, Hyoung Jin Kim, Yoo Ri Choi, Hong-Jin Kim
https://www.sciencedirect.com/science/article/pii/S0264410X11020810
These emulsion adjuvants were investigated for their ability to induce antigen-specific immune responses, and the relationship between immune activation, cell death, and the kinetics of antigen delivery was examined. 3.1. Phagocytosis and uptake of adjuvant-treated cells by …Author: Shan-Shan Shen, Ya-Wun Yang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970548/
Jan 06, 2020 · (b) Adjuvanted vaccines, in turn, enhance the quality and quantity of antigen presenting cell maturation and costimulation, T helper-polarizing cytokine production, polyfunctional T cells, and antibody production, resulting in broad and durable immunity, as well as dose and antigen sparing. Multiple cell colors indicate broader protective immunity.Author: Etsuro Nanishi, David J. Dowling, Ofer Levy
https://www.nature.com/articles/srep15907
Oct 29, 2015 · New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with ...Author: Alizée J. Grimm, Stephan Kontos, Giacomo Diaceri, Xavier Quaglia-Thermes, Jeffrey A. Hubbell
https://www.sciencedirect.com/science/article/pii/S0168365912005810
Induction of potent CD8 + T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely ... Having shown that NP delivery of antigen gives superior CD8 + T cell responses when compared to ... inducing localised cell death producing cytokines/chemokines to help activate nearby abundant APCs that ...Author: Hwee-Ing Ng, Germain J.P. Fernando, Mark A.F. Kendall
https://www.researchgate.net/scientific-contributions/9977537_Ya-Wun_Yang
Ya-Wun Yang's 24 research works with 316 citations and 365 reads, including: Recruitment of bone marrow CD11b+Gr-1+ cells by polymeric nanoparticles for antigen cross-presentation
https://link.springer.com/10.1007/s00018-019-03429-2
Jan 01, 2020 · In this study, we determined the anticancer effect of a newly found natural compound, sakurasosaponin (S-saponin), using androgen-dependent and castration-resistant PCa cell lines. S-saponin induces mitochondrial-mediated cell death in both androgen-dependent (LNCaP) and castration-resistant (22Rv1 and C4-2) PCa cells, via AR expression.Author: In-Sung Song, Yu Jeong Jeong, Jueun Kim, Kyoung-Hwa Seo, Nam-In Baek, Yunlim Kim, Choung-Soo Kim, Su...
https://www.hindawi.com/journals/jo/2020/9593516/
This means there was a nonspecific effect of IT with saponin without the formation of the antigen-antibody complex. ... and ASAP-KGI induces cancer cell death through ... that the saporin-conjugated anti-Robo1 immunotoxin comprises a novel therapeutic target in HNSCC by the application of saponin, and the drug delivery system developed here ...Author: Noriko Komatsu, Noriko Komatsu, Miku Komatsu, Riuko Ohashi, Akira Horii, Kazuto Hoshi, Tsuyoshi Taka...
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