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https://www.ncbi.nlm.nih.gov/pubmed/11014404
On the basis of in vitro studies demonstrating that loperamide is a substrate for the adenosine triphosphate-dependent efflux membrane transporter P-glycoprotein, we postulated that inhibition of P-glycoprotein with quinidine would increase entry of loperamide into the central nervous system with resultant respiratory depression.Cited by: 532
https://ascpt.onlinelibrary.wiley.com/doi/full/10.1067/mcp.2000.109156
This study therefore demonstrates first the potential for important drug interactions to occur by a new mechanism, namely, inhibition of P‐glycoprotein, and second that the lack of respiratory depression produced by loperamide, which allows it to be safely used therapeutically, can be reversed by a drug causing P‐glycoprotein inhibition ...Cited by: 532
https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1067/mcp.2000.109156
On the basis of in vitro studies demonstrating that loperamide is a substrate for the adenosine triphosphate–dependent efflux membrane transporter P‐glycoprotein, we postulated that inhibition of P‐glycoprotein with quinidine would increase entry of loperamide into the central nervous system with resultant respiratory depression.Cited by: 532
https://www.researchgate.net/publication/12310124_Increased_drug_delivery_to_brain_by_P-glycoprotein
MRI-guided focused ultrasound (MRgFUS) combined with microbubbles (MBs) is a promising technology that can facilitate drug delivery through a temporarily disrupted blood-brain barrier (BBB…
https://selinashah.com/hand-assisted-laparoscopic-adical-nephrectomy-associated-rhabdomyolysis-with-arf/
Jan 04, 2003 · Increased Drug Delivery to the Brain by P-Glycoprotein Inhibition - Selina Shah Although the antidiarrheal loperamide is a potent opiate, it does not produce opioid central nervous system effects at usual doses in patients.
https://drugs-forum.com/threads/increased-drug-delivery-to-the-brain-by-p-glycoprotein-inhibition.172470/
Nov 30, 2011 · To check it out, rate it or add comments, visit Increased drug delivery to the brain by P-glycoprotein inhibition The comments you make there will appear in the posts below. Nov 29, 2011 #2
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