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https://www.ncbi.nlm.nih.gov/pubmed/10779767
May 01, 2000 · In addition, the immunogenicity of a potent HIV gag DNA vaccine was increased in mice, as seen by higher Ab titers, a substantial reduction in the dose of DNA required to induce an Ab response, and an increase in CD8+ T cell responses.Author: Georg Widera, Melissa Austin, Dietmar Rabussay, Cheryl Goldbeck, Susan W. Barnett, Minchao Chen, Lou...
https://pdfs.semanticscholar.org/daef/215e1524dbbda43228979999cfdb500748e6.pdf
electroporation to facilitate DNA delivery in vivo. This technology was shown to substantially increase delivery of DNA to cells, resulting in increased expression and elevated immune responses.
https://www.researchgate.net/publication/12536525_Increased_DNA_Vaccine_Delivery_and_Immunogenicity_by_Electroporation_In_Vivo
To overcome the limitations of DNA vaccine, researchers have developed new delivery systems, including electroporation. For example, the efficacy of hepatitis B surface antigen and human...
http://www.nature.com/articles/emm200876
Dec 31, 2008 · Increased <i>in vivo</i> immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation Skip to main content Thank you for visiting nature.com.Author: Chae Young Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209024/
Currently, electroporation is the most effective method for DNA vaccine delivery (16, 30, 32). Electroporation increases antigen (Ag) expression in muscle and skin 10- to 100-fold more than a direct injection, which leads to increased immunogenicity, a more durable response, and a reduced efficient dose in sheep, pigs, and other large animals.Author: Hong Chen, Bo Wen, Bo Wen, Yao Deng, Wen Wang, Xiao Yin, Jie Guan, Li Ruan, Wenjie Tan
https://www.semanticscholar.org/paper/Immunogenicity-by-Electroporation-In-Vivo-Increased-Otten-Thudium/daef215e1524dbbda43228979999cfdb500748e6
@inproceedings{Otten2000ImmunogenicityBE, title={Immunogenicity by Electroporation In Vivo Increased DNA Vaccine Delivery and Ulmer}, author={Gillis R. Otten and Kent Thudium and Mark Joseph Selby and Jeffrey B. Goldbeck and Susan W. Barnett and Minchao Chen and Louisa Leung and Georg Widera and ...
https://www.nature.com/articles/s41598-017-04547-2
Jun 23, 2017 · In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to vaccine antigens delivered through the skin.Author: Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
The observation that in vivo electroporation can dramatically improve gene delivery has led to a great deal of interest to assess the consequences of this delivery to enhancing immunogenicity and effectiveness of DNA vaccines in specific model systems. While it has been difficult to quantitatively measure directly the enhancement in plasmid delivery and its translation to increased transgene expression, and consequent induction of immune …Author: Niranjan Y Sardesai, David B Weiner
https://www.ncbi.nlm.nih.gov/pubmed/21603651
BACKGROUND: DNA-based vaccines have been safe but weakly immunogenic in humans to date. METHODS AND FINDINGS: We sought to determine the safety, tolerability, and immunogenicity of ADVAX, a multigenic HIV-1 DNA vaccine candidate, injected intramuscularly by in vivo electroporation (EP) in a Phase-1, double-blind, randomized placebo-controlled ...Author: Sandhya Vasan, Sandhya Vasan, Arlene Hurley, Arlene Hurley, Sarah J. Schlesinger, Sarah J. Schlesing...
https://www.sciencedirect.com/science/article/pii/S095279152030008X
Recently newer synthetic DNA vaccines have been rapidly advanced to clinical study and have demonstrated an impressive degree of immune potency and to…
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