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https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Because of its potency, siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task. This article describes an RNAi experiment in an animal model in which siRNA was administered using hydrodynamic tail vein injection.
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro). Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.sciencedirect.com/science/article/pii/S0168365918300774
In vivo polyplex accumulation following pulmonary delivery The delivery of therapeutic siRNA has long been proposed as an attractive treatment option for a variety of different pulmonary diseases with several nanoparticle-based siRNA treatments having entered different clinical phases [ 30 ].Author: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sha...
https://altogen.com/transfection-resource/in-vivo-sirna-transfection/
In Vivo siRNA Transfection (animal siRNA delivery) In vivo methods require live animal systems where the desired molecule is delivered into the animal or locally to specific tissues. The immune response of the animal will influence the transfection efficiency.
https://www.pnas.org/content/104/32/12982
Aug 07, 2007 · Effective in vivo delivery of siRNA to the appropriate target cell is an essential component of these siRNA-based applications. Accordingly, a variety of nonviral (4 – 14) and viral (15 – 17) systems are being developed for delivery of siRNA to liver, tumors, and other tissues in vivo.Author: David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
May 05, 2010 · To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifies the small RNAs residing in the RISC from the tissues of rodents and monkey. Application of our approach to preclinical animal studies yielded quantitative insights into the in vivo efficiency of siRNA delivery and the mechanism of RNA silencing.Author: Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pom...
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Here we show how exosomes derived from cultured cells can be harnessed for delivery of siRNA in vitro and in vivo. This protocol first describes the …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.researchgate.net/post/What_is_the_best_way_of_delivering_siRNA_in_vivo
We used Mirus TransIT In Vivo Gene Delivery System. We infused the siRNA with this delivery system directly into the renal capsule to knock down cav1 expression in rats. We were able to reduce...
http://www.invivotransfection.com/
In Vivo Transfection In Vivo Background . With modern genetic techniques allowing scientists to identify the link between genes and diseases, there is an enormous emphasis on determining ways to alter the function of a gene in vivo.Strategies to treat these diseases include delivering an alternate gene to the cell, replacing the defective gene or silencing the defective gene using RNAi or ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
For In vivo experiment, miRNAs delivered by PLGA nanoparticles were accumulated in the tumor tissues 24 h after injection. Thus, the miRNA antagonists containing PEGylated-PLGA nanoparticles may achieve great therapeutic effect In vivo . Babar et al. examined whether the induction or withdrawal of miR-155 expression would cause tumor regression.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
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