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https://www.researchgate.net/publication/234140538_in_vivo_delivery_aspects_of_miRNA_shRNA_and_siRNA
in vivo delivery aspects of miRNA, shRNA and siRNA Article · Literature Review (PDF Available) in Critical Reviews in Therapeutic Drug Carrier Systems · January 2012 with 268 Reads
https://www.researchgate.net/publication/233766241_In_vivo_delivery_aspects_of_miRNA_shRNA_and_siRNA
In vivo delivery aspects of miRNA, shRNA and siRNA. ... However, in vivo delivery of RNAi therapeutics is restricted because of charge density, molecular weight, and instability in the presence of ...
https://www.ncbi.nlm.nih.gov/pubmed/23176057
In vivo delivery aspects of miRNA, shRNA and siRNA. Khatri N(1), Rathi M, Baradia D, Trehan S, Misra A. Author information: (1)Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat State, India.Author: N. I. Khatri, Mohan N. Rathi, D. P. Baradia, S. Trehan, Ambikanandan Misra
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,63fbc8132cd41834,3a78dc712b45da17.html
Home > Journals > Critical Reviews™ in Therapeutic Drug Carrier Systems > Volume 29, 2012 Issue 6 > In Vivo Delivery Aspects of miRNA, shRNA and siRNA. IF: ... In Vivo Delivery Aspects of miRNA, shRNA and siRNA. N. I. Khatri Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan ...
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Technology exploiting this phenomenon may be used for functional genomics and target validation, and is being developed for therapeutic purposes. Because of its potency, siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task.
https://www.sciencedirect.com/science/article/pii/S2162253116300373
siRNA Versus miRNA as Therapeutics for Gene Silencing ... of the early generation polymers studied for nucleic acid delivery. 129 It is the most widely investigated polymer for siRNA and miRNA delivery in vivo. 130, 131 Because of its high ... K Terasawa, K Shimizu, G TsujimotoSynthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers. J Nucleic ...Author: Jenny K W Lam, Jenny K W Lam, Michael Y T Chow, Yu Zhang, Susan W S Leung, Susan W S Leung
https://www.gene-quantification.de/pushparaj-sarna-in-vivo-applications-2008.pdf
J Dent Res 87(11) 2008 In vivo Applications of siRNA, miRNA, and shRNA 993 In vivo APPLICATIONS OF RNAi RNAi has been used to generate model systems, to identify novel molecular targets, to study gene function in a genome-wide manner, and to create a new niche for clinical therapeutics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877448/
Sep 15, 2015 · siRNA Versus miRNA as Therapeutics for Gene Silencing ... of the early generation polymers studied for nucleic acid delivery. 129 It is the most widely investigated polymer for siRNA and miRNA delivery in vivo. 130,131 Because of its high transfection ... Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers. J Nucleic Acids 2011: 131579 ...Author: Jenny K W Lam, Jenny K W Lam, Michael Y T Chow, Yu Zhang, Susan W S Leung, Susan W S Leung
http://europepmc.org/abstract/MED/23176057
Jan 01, 2012 · However, in vivo delivery of RNAi therapeutics is restricted because of charge density, molecular weight, and instability in the presence of nucleases. Furthermore, intracellular accumulation and endosomal escape have remained significant barriers in the delivery of these macromolecules.Author: N. I. Khatri, Mohan N. Rathi, D. P. Baradia, S. Trehan, Ambikanandan Misra
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